| Issue | #21 |
| Published | May 2010 |
| Cover Price | 2.99 USD |
| Pages | 36 |
| Editing | Axel Alonso; Jody Leheup (Assistant) |
| Characters | Deadpool; Spider-Man; Hit-Monkey |
| Genre | superhero |
| Pencils | Jason Pearson |
| Inks | Jason Pearson |
| Letters | Typeset |
| Genre | superhero |
| Pencils | Carlo Barberi |
| Inks | Sandu Florea |
| Colors | Marte Gracia |
| Letters | Typeset |
| Characters | Deadpool; GUESTS: Spider-Man; Fantastic Four--Mr. Fantastic; Invisible Woman; Human Torch; The Thing; VILLAIN: Hit-Monkey |
| Synopsis | Deadpool and Spider-Man are recovering at the Baxter Building from an assault by Hit-Monkey when DP makes off with Spidey's costume and sneaks out the bathroom window; 'Pool fakes Spidey's death to draw Hit-Monkey out and is wildly successful as the deadly simian comes to the funeral; Unfortunately, when Deadpool springs from the coffin to confront his foe, the police seem much more worried about a machine gun toting mercenary than they are about a monkey in a suit; Spidey and Deadpool battle Hit-Monkey once again and things end in an explosive climax; Spidey gives 'Pool a lecture on being an angst ridden hero. |
| Genre | superhero |
| Script | Daniel Way |
| Pencils | Carlo Barberi |
| Inks | Sandu Florea |
| Colors | Marte Gracia |
| Letters | Virtual Calligraphy's Joe Sabino |
| Characters | Deadpool |
| Genre | superhero |
| Pencils | Jason Pearson |
| Inks | Jason Pearson |
| Letters | Typeset |
| Notes | Presents full page cover art for next issue. |