| Issue | #5 |
| Published | February 2008 |
| Cover Price | 4.99 USD |
| Pages | 72 |
| Editing | Tom Brevoort; Axel Alonso; Michael O'Connor (Assistant); Molly Lazer (Assistant); Aubrey Sitterson (Assistant) |
| Characters | Professor X; Cyclops; Nightcrawler; Iceman; Moon Knight; Sasquatch; Punisher; Black Widow; Cloak; Dagger; Ghost Rider; She-Hulk; Sentry; Patriot; Hulkling; Wiccan; Hawkeye [Kate Bishop]; Captain America; Mr. Fantastic; Invisible Woman; The Thing; Human Torch; Namor, the Sub-Mariner; Spider-Man; Daredevil; Iron Man; Wolverine; Spider-Woman; Dr. Strange; Nova; Black Panther; Black Bolt; Medusa; Gorgon; Black Cat; Falcon; Silver Surfer; Hulk; Deadpool; Hercules; Iron Fist; Wonder Man; Captain Britain; Union Jack; Radioactive Man; Speedball; Namorita; Songbird; Luke Cage; Stature; Nick Fury; Atlas; Guardian [James MacDonald Hudson]; Puck; Microbe; Nico Minoru; Chase Stein |
| Genre | superhero |
| Pencils | Steve McNiven |
| Inks | Dexter Vines |
| Colors | Morry Hollowell |
| Letters | Typeset |
| Reprinted | From Civil War Files (Marvel, 2006 series) #nn Cover |
| Genre | superhero |
| Pencils | Various |
| Inks | Various |
| Colors | Various |
| Letters | Typeset |
| Characters | FEATURE: Spider-Man; GUESTS: Iron Man; Captain America; Ms. Marvel; She-Hulk; Yellowjacket [Hank Pym]; Wasp; Daredevil; Luke Cage; Cloak; Dagger; CAMEO FLASHBACK: The Thing; Hercules; Doc Samson; Falcon; Goliath [Bill Foster]; Wonder Man; Vision; Cable; Invisible Woman; Speed |
| Synopsis | Spidey helps Iron Man protect a prison convoy of captured heroes but Cap and his allies decide to try and mount a rescue; Spidey and Cap battle. |
| Genre | superhero |
| Script | J. Michael Straczynski |
| Pencils | Ron Garney |
| Inks | Bill Reinhold |
| Colors | Matt Milla |
| Letters | Virtual Calligraphy's Cory Petit |
| Notes | This story takes place simultaneously with Fantastic Four #539. |
| Reprinted | From Amazing Spider-Man (Marvel, 2003 series) #534 (Sept. 2006) |
| Characters | FEATURE: The Thing; GUESTS: Captain America; Daredevil; Luke Cage; Cloak; Dagger; Spider-Man; Iron Man; She-Hulk; Yellowjacket [Hank Pym]; Wasp; Ms. Marvel; Tigra; Yancy Street Gang; VILLAINS: The Thinker; Puppet Master; CAMEO FLASHBACK: Mr. Fantastic; Invisible Woman; Human Torch |
| Synopsis | The Puppet Master and the Thinker choose a clash between Iron Man's forces and Cap's forces during a prisoner transport to strike out at the heroes and cause additional havoc; When a member of the Yancy Street Gang is killed in the conflict, the Thing verbally lays into the heroes on both sides of the Civil War conflict and declares that he is leaving the country until the superhuman registration mess is sorted out. |
| Genre | superhero |
| Script | J. Michael Straczynski |
| Pencils | Mike McKone |
| Inks | Andy Lanning; Kris Justice; Cam Smith |
| Colors | Paul Mounts |
| Letters | Virtual Calligraphy's Rus Wooton |
| Notes | This story takes place simultaneously with Amazing Spider-Man #534. |
| Reprinted | From Fantastic Four (Marvel, 2003 series) #539 (Sept. 2006) |
| Characters | She-Hulk; Luke Cage |
| Genre | superhero |
| Pencils | Various |
| Inks | Various |
| Colors | Various |
| Letters | Typeset |
| Characters | Spider-Man; Captain America |
| Genre | superhero |
| Pencils | Ron Garney |
| Inks | Ron Garney |
| Reprinted | From Amazing Spider-Man (Marvel, 2003 series) #534 (Sept. 2006) Cover detail |
| Characters | FEATURE: Fantastic Four--Mr. Fantastic; Invisible Woman; The Thing; GUESTS: Iron Man; Peter Parker [Spider-Man]; Wildstreak |
| Synopsis | When Sue helps Wildstreak escape from the Baxter Building against her husband's wishes, the couple fight and the Civil War splits the Richard's family right down the middle; The Thing also deserts Reed by informing him that he is leaving the country until the superhuman registration mess is cleared up; Tony and Peter stop by to take a look at the new superhuman prison that Mr. Fantastic has set up in the Negative Zone. |
| Genre | superhero |
| Script | J. Michael Straczynski |
| Pencils | Mike McKone |
| Inks | Andy Lanning; Cam Smith |
| Colors | Paul Mounts |
| Letters | Virtual Calligraphy's Rus Wooton |
| Reprinted | From Fantastic Four (Marvel, 2003 series) #540 (Nov. 2006) |