| Issue | #22 |
| Published | September 2003 |
| Cover Price | $2.95 |
| Pages | 36 |
| Editing | ? |
| Characters | Serpentor; Dr. Mindbender; Hannibal; Cloned Children |
| Genre | war |
| Pencils | Michael Turner |
| Inks | Michael Turner |
| Characters | FEATURE: G.I. Joe--Hawk; Snake-Eyes; Beach Head; Cover Girl; Lifeline; Daemon (Death); Firewall; Rock 'N Roll; Spirit Iron-Knife; Roadblack; Greenshirts; GUEST: Jugglers; VILLAINS: Dr. Mindbender; Serpentor; Firefly; The Coil; BATS; Hannibal; Julius; Ivan; Alexander; Attila; Genghis; Vlad; Philip; Napoleon; Thomas; CAMEO FLASHBACK: Cobra Commander; Zartan; Croc Master; Billy |
| Synopsis | Serpentor is resurrected and saves his "children" from the Joes as he begins his bid for world domination. |
| Genre | war |
| Script | Josh Blaylock |
| Pencils | Brandon Badeaux |
| Inks | Andrew Pepoy |
| Colors | Brett R. Smith |
| Letters | Dreamer Design |