| Issue | #25 |
| Published | March 2008 |
| Cover Price | 2.99 USD; 3.65 CAD |
| Pages | 36 |
| Editing | Matt Idelson; Tom Palmer, Jr. (assistant editor) |
| Characters | Supergirl [Kara Zor-El]; Reactron |
| Genre | superhero |
| Pencils | Drew Johnson (signed) |
| Inks | Ray Snyder (signed) |
| Colors | Brad Anderson (signed) |
| Characters | Supergirl [Kara Zor-El]; Superman [Clark Kent]; Lois Lane (cameo); Batman (cameo); Reactron |
| Synopsis | After having a conversation in outer space with Superman, Supergirl is attacked by the mysterious villain named Reactron. |
| Genre | superhero |
| Script | Kelley Puckett |
| Pencils | Drew Johnson; Lee Ferguson |
| Inks | Ray Snyder |
| Colors | Brad Anderson |
| Letters | Jared K. Fletcher |