| Issue | #45 |
| Published | July 2008 |
| Frequency | monthly |
| Cover Price | 2.25 USD |
| Pages | 36 |
| Editing | Ian Sattler |
| Characters | Bloo; Grim; Bubbles; Buttercup; Blossom |
| Genre | humor |
| Pencils | Robert Pope (signed) |
| Inks | Mike DeCarlo (signed) |
| Characters | Bloo; Max; Wilt; Eduardo; Mr. Herriman |
| Synopsis | Everyone wants to keep Bloo from knowing that they are painting at the house, because he always gets carried away when paint is involved. |
| Genre | humor |
| Script | Scott Cunningham |
| Pencils | Robert Pope |
| Inks | Jeff Albrecht |
| Colors | Heroic Age |
| Letters | Travis Lanham |
| Characters | Grim; Mandy; Billy |
| Synopsis | When Billy resets the Cosmic Cuckoo Clock (for Daylight Savings Time) he and Mandy are set adrift in time and meet future (and past) versions of themselves. |
| Genre | humor |
| Script | Paul Kupperberg |
| Pencils | Christopher Cook |
| Inks | Mike DeCarlo |
| Colors | Heroic Age |
| Letters | Travis Lanham |
| Characters | Bubbles; Blossom; Buttercup; Mojo Jojo |
| Synopsis | Mojo Jojo sends hundreds of identical robots to attack Townsville, and the Powerpuff Girls must discover which one is the controller robot that can stop all the others. |
| Genre | superhero; humor |
| Script | John Rozum |
| Pencils | Phil Moy |
| Inks | Phil Moy |
| Colors | Heroic Age |
| Letters | Travis Lanham |
| Synopsis | No letters this issue; Johnny DC writes about a new series on Cartoon Network (The Misadventures of Flapjack) and also a bit about the history of kids' comics at DC. |
| Script | ? [as Johnny DC] |
| Pencils | ? (illustrations) |
| Inks | ? (illustrations) |
| Colors | ? (illustrations) |
| Letters | typeset |