| Issue | #1 |
| Published | July 2008 |
| Cover Price | 2.99 USD; 2.99 CAD |
| Pages | 36 |
| Editing | Shelly Bond (Co-Editor); Angela Rufino (Co-Editor) |
| Notes | Regular cover. |
| Genre | Occult |
| Pencils | Sam Weber |
| Inks | Sam Weber |
| Notes | Regular cover. |
| Genre | Occult |
| Pencils | Bernie Wrightson |
| Inks | Bernie Wrightson |
| Notes | Variant Cover. |
| Characters | Cain; Abel; Fig Keele; Ann Preston; Rina; Cress; The Poet; Harry Bailey; The Coachman; Hungry Sally |
| Synopsis | A young woman who dreams of the House of Mystery all her life finds the House. |
| Genre | Occult |
| Script | Matthew Sturges |
| Pencils | Luca Rossi |
| Inks | Luca Rossi |
| Colors | Lee Loughridge |
| Letters | Todd Klein |
| Characters | Hungry Sally; Albert Crimp |
| Synopsis | Hungry Sally tells her story of giving birth to Albert Crimp's children. |
| Genre | Occult |
| Script | Bill Willingham |
| Pencils | Ross Campbell |
| Inks | Ross Campbell |
| Colors | Ross Campbell (?) |
| Letters | Todd Klein |
| Characters | Matthew Sturges (photo); Bill Willingham (photo) |
| Synopsis | Matthew Sturges and Bill Willingham talk about their new series House of Mystery. |
| Script | Matthew Sturges; Bill Willingham |
| Pencils | ? (photo); ? |
| Inks | ? (photo); ? |
| Colors | ? (photo); ? |
| Letters | Typeset |
| Notes | Hot list - VERTIGO: FIRST CUT #nn, FABLES #73, CROSSING MIDNIGHT #19, THE EXTERMINATORS VOL. 4: CROSSFIRE AND COLLATERAL #nn and ABSOLUTE SANDMAN #3. |