| Issue | #2 |
| Published | November 2008 |
| Frequency | monthly |
| Cover Price | 2.99 USD; 3.05 CAN |
| Pages | 36 |
| Editing | Nick Lowe; Daniel Ketchum (assistant) |
| Characters | Karolina Dean; Xavin |
| Genre | superhero |
| Pencils | Humberto Ramos (signed) |
| Inks | Humberto Ramos (signed) |
| Colors | Humberto Ramos ? |
| Synopsis | An anti-smoking advertisement from the Office of National Drug Control Policy. |
| Notes | inside front cover |
| Letters | typeset |
| Characters | Karolina Dean; Xavin; DeHalle; Nico Minoru; Chase Stein; Victor Mancha; Molly Hayes; vaDanti; Molly; Old Lace; vaRikk |
| Synopsis | The team is attacked by a group of Majesdanians whom Nico teleports away with a "scatter" spell. |
| Genre | superhero |
| Script | Terry Moore |
| Pencils | Humberto Ramos |
| Inks | Dave Meikis |
| Colors | Christina Strain |
| Letters | Joe Caramagna [as VC's Joe Caramagna] |
| Synopsis | An advertisement for Microsoft's computer game, "Viva PiƱata: Trouble in Paradise." |
| Notes | This advertisement is between pages 3 and 4 of the Runaways story. |
| Synopsis | An advertisement for on-line comicbook retailer, "Mail Order Comics." |
| Notes | This advertisement is between page 6 of the Runaways story and the Fable II advertisement. |
| Synopsis | An advertisement for the Microsoft computer game, "Fable II." |
| Notes | This advertisement is between the Mail Order Comics advertisement and page 7 of the Runaways story. |
| Synopsis | An in-house promotional advertisement for Marvel's event, "Secret Invasion," featuring two human children and one Skrull child. |
| Notes | This advertisement is between pages 10 and 11 of the Runaways story. |
| Synopsis | An advertisement for Disguise's children's Halloween costumes featuring licensed Marvel characters and available at Target stores. |
| Notes | This advertisement is between pages 13 and 14 of the Runaways story. |
| Synopsis | An in-house promotional advertisement for the Amazing Spider-Man (Marvel, 2003 series) #573. |
| Notes | This advertisement is between pages 16 and 17 of the Runaways story. |
| Synopsis | An in-house promotional advertisement for Marvel's "Ultimatum" event. |
| Notes | This advertisement is between pages 17 and 18 of the Runaways story. |
| Synopsis | An in-house promotional advertisement for Astonishing X-Men: Ghost Boxes (Marvel, 2008 series) #1. |
| Notes | This advertisement is between pages 18 and 19 of the Runaways story. |
| Synopsis | An advertisement for Old Spice's "Red Zone" body wash. |
| Notes | This advertisement follows the final page of the Runaways story and is on the inside back cover. |
| Synopsis | An advertisement for the Gamecock computer game, "Mushroom Men in the Spore Wars and Rise of the Fungi." |
| Notes | back cover. |