| Issue | #490 |
| Published | June 2008 |
| Cover Price | 4.99 USD |
| Pages | 52 |
| Editing | John Ficarra |
| Characters | Alfred E. Neuman |
| Synopsis | Alfred in Indiana Jones's familiar garb. |
| Genre | satire |
| Pencils | Mark Fredrickson |
| Inks | Mark Fredrickson |
| Letters | typeset |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Notes | Ad for game from Temco Ltd. On inside front cover. |
| Characters | Alfred E. Neuman; Super Delegate; Indiana Jones; Deathster; Lizz LemonPledge |
| Pencils | various |
| Inks | various |
| Letters | typeset |
| Notes | Art is from various places in the magazine. The feature "Optimus Prime Rib Department" is phony and does not actually appear in the issue. |
| Synopsis | Ad for May 27th 2008 DVD releases from Bird Studio/Shueisha and Toei Animation. |
| Letters | typeset |
| Notes | Occupies bottom halves of first 2 pages of letters pages. |
| Characters | Alfred E. Neuman; Matisyahu; Jonathan Bresman |
| Synopsis | Includes the editor's Nifty Fifty of celebrities to photograph with a copy of MAD for the coming year. |
| Script | John Ficarra |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Letters | typeset |
| Notes | Letters, photos and fan art from: Craig Kleinpeter; Kevin Killermann; Victor Gratt; Steve Haller; Jeanette Handling; Tony Comunale; Rachel Nussbaum; Ed Meisinger; Royan Iranpour; April Harris; Jason Reeves; Ryan Castillo; Peter & Janelle Hernandez; Colton Walker |
| Genre | fact |
| Letters | typeset |
| Characters | Barack Obama; Hillary Clinton; John McCain; Jenna Jameson; Fat Steve; Joe Bitterman; Nick |
| Synopsis | Various short satires of pop culture. |
| Genre | humor |
| Script | various |
| Pencils | various |
| Inks | various |
| Letters | typeset |
| Notes | Contributors (roles unknown) include: Paul Coker; Dick DeBartolo; Evan Dorkin; Sarah Dyer; Garth Gerhart; Darren Johnson; Jeff Kruse; Jacob Lambert; Randy McIlwane; Bob Staake; Ward Sutton; Rick Tulka |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Notes | Ad for the following MAD books: Spy Vs. Spy 2; MAD About Star Wars; The MAD War on Bush; The Completely MAD Don Martin. |
| Characters | Crazee Jumpin; Lizz LemonPledge; Jock Dungaheap; Henna Baloney; Jane Krackheadski; Lorne Michaels (cameo); Kennel; Hannah Montana (cameo); Crank |
| Synopsis | A typical day at the studios at 30 Crock. |
| Genre | satire |
| Script | Arnie Kogen |
| Pencils | Tom Richmond |
| Inks | Tom Richmond |
| Letters | typeset |
| Notes | Parody of tv show 30 Rock. |
| Notes | Ad for books in the Uglydoll series from Random House, by David Horvath and Sun-Min Kim. |
| Characters | Bill Clinton; Hillary Clinton; Barack Obama; Michelle Obama |
| Synopsis | Bill, in his secret identity as SuperDelegate, stops the Obama campaign dead. |
| Genre | satire; superhero |
| Script | Joe Raiola |
| Pencils | R. Sikoryak |
| Inks | R. Sikoryak |
| Notes | A parody of the Silver Age Superman comic plots, drawn in a similar style. |
| Characters | Steven Spielberg; George Lucas (printed word) |
| Synopsis | A fake letter of ideas for the Indiana Jones and the Kingdom of the Crystal Skull movie. |
| Genre | humor |
| Script | David Shayne |
| Pencils | Jack Syracuse |
| Inks | Jack Syracuse |
| Letters | typeset |
| Synopsis | Various things that might go wrong with typical science fair projects. |
| Genre | humor |
| Script | Sergio Aragones |
| Pencils | Sergio Aragones |
| Inks | Sergio Aragones |
| Characters | Embryonic Jones |
| Script | Desmond Devlin |
| Pencils | Richard Williams |
| Inks | Richard Williams |
| Letters | typeset |
| Notes | Parody of an Indiana Jones movie poster. |
| Characters | Jeffrey Lozenge |
| Synopsis | A message on ? |
| Script | Jeffrey Lozenge ? |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Notes | House ad for Mad subscriptions; #3 in a series. |
| Characters | Monroe; Mr. Bines; Johab; Johab's father; Johab's mother; Monroe's mother; Monroe's father |
| Synopsis | Monroe is paired with a new, home-schooled, Christian boy for a homework assignment. |
| Genre | humor |
| Script | Anthony Barbieri |
| Pencils | Tom Fowler |
| Inks | Tom Fowler |
| Colors | Ryan Flanders |
| Letters | typeset |
| Notes | Shows covers to several issues of MAD Classics and also MAD #166. |
| Characters | Iron Man [Tony Stark]; Pepper |
| Genre | satire |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Notes | Movie stills with fake dialog. |
| Synopsis | Fake ad to look like Whole Foods Market circular. |
| Genre | satire |
| Script | Kiernan P. Schmitt |
| Letters | typeset |
| Characters | Brian; Angela |
| Synopsis | Brian refuses a prom invitation from Angela. |
| Genre | humor |
| Script | Ted Rall |
| Pencils | Ted Rall |
| Inks | Ted Rall |
| Letters | Ted Rall |
| Characters | Vanessa Anne Hudgens; Zac Efron; Roger; Black Spy; White Spy; Dwayne; Wall-E |
| Synopsis | Various pages from recent MADKids issues. |
| Script | various |
| Pencils | various |
| Inks | various |
| Letters | typeset |
| Notes | House ad for MADKids current issue and subscriptions. |
| Characters | Indiana Jones; Robert Langdon |
| Synopsis | A look at other things that might bug Indiana Jones. |
| Genre | satire |
| Script | John Caldwell |
| Pencils | John Caldwell |
| Inks | John Caldwell |
| Letters | typeset |
| Characters | Black Spy; White Spy |
| Synopsis | The White Spy is camouflaged so well that the Black Spy destroys several things thinking they are the White Spy. |
| Genre | humor |
| Script | Peter Kuper |
| Pencils | Peter Kuper |
| Inks | Peter Kuper |
| Characters | Deathster Morgue'in; Angel Badteaser; Tom Asstore; Maria Lagrabba; Debrat; Scary Morgue'in; Sgt. Croakes; Vince Masukka; Reepa; Liar |
| Synopsis | A typical week in the life of Deathster, with a flashback to his youth. |
| Genre | satire |
| Script | Charlie Kadau |
| Pencils | Hermann Mejia |
| Inks | Hermann Mejia |
| Letters | typeset |
| Notes | Parody of the tv show Dexter. |
| Characters | Indiana Jones; Alfred E. Neuman |
| Synopsis | Cover of MAD #228 with a variation to find the differences on. |
| Pencils | Jack Rickard |
| Inks | Jack Rickard |
| Letters | typeset |
| Notes | Answer included. |
| Reprinted | From Mad #228 (EC, 1952 series) |
| Letters | typeset |
| Notes | Ad for a Shonen Jump DVD set. |
| Characters | John McCain |
| Synopsis | Answer is: John McCain. |
| Genre | humor |
| Script | Al Jaffee |
| Pencils | Al Jaffee |
| Inks | Al Jaffee |
| Letters | typeset |
| Notes | Inside back cover. |
| Genre | gags |
| Script | Sergio Aragones |
| Pencils | Sergio Aragones |
| Inks | Sergio Aragones |
| Notes | Gags appear on 12 different pages. |
| Letters | typeset |
| Notes | Ad for book "Blood Captain" in the Vampirates series from Little, Brown and Company. |