| Issue | #2 |
| Published | November 2008 |
| Cover Price | 2.99 USD |
| Pages | 36 |
| Editing | Axel Alonso; Jody Leheup (Assistant) |
| Characters | Deadpool; Skrull Deadpools |
| Genre | superhero |
| Pencils | Clayton Crain (Painted) |
| Inks | Clayton Crain (Painted) |
| Colors | Clayton Crain (Painted) |
| Letters | Typeset |
| Characters | Deadpool; Skrulls |
| Genre | superhero |
| Pencils | Ed McGuinness |
| Letters | Typeset |
| Characters | Deadpool |
| Genre | superhero |
| Pencils | Paco Medina |
| Inks | Juan Vlasco |
| Colors | Marte Gracia |
| Letters | Typeset |
| Notes | Wraparound cover; 2nd Print variant utilizes an interior double page splash as the cover image. |
| Genre | superhero |
| Pencils | Paco Medina |
| Inks | Juan Vlasco |
| Colors | Marte Gracia |
| Letters | Typeset |
| Characters | FEATURE: Deadpool; VILLAINS: Skrulls; Super Skrull; Skrull Deadpools; CAMEO: Nick Fury; CAMEO FLASHBACK: Dr. Killebrew; Ajax |
| Synopsis | Deadpool offers to work for the Skrulls but, instead, they decide to dissect him and figure out what makes him tick; Discovering that he has an extraordinary healing factor, the Skrulls implement this little genetic advantage into the next batch of Super Skrulls; Deadpool convinces his Skrull captors to let him train the new army of Skrull Deadpools and does so by pitting them against the regular Super Skrulls and against each other; Watching their new breed of warriors killing each other off, the Skrull command realizes too late that Deadpool is plain crazy; What they don't know, however, is that he is also secretly working for Nick Fury. |
| Genre | superhero |
| Script | Daniel Way |
| Pencils | Paco Medina |
| Inks | Juan Vlasco |
| Colors | Marte Gracia |
| Letters | Virtual Calligraphy's Cory Petit |
| Characters | Deadpool; Super Skrull |
| Genre | superhero |
| Pencils | Clayton Crain (Painted) |
| Inks | Clayton Crain (Painted) |
| Colors | Clayton Crain (Painted) |
| Letters | Typeset |
| Notes | Presents full page cover art for next issue. |