| Issue | #48 |
| Published | November 2009 |
| Cover Price | 2.99 USD |
| Pages | 36 |
| Editing | Jody LeHeup |
| Notes | U.S. on sale date: 2009-09-16. © 2009 Marvel Characters, Inc. |
| Characters | X-Factor [Longshot; M [Monet St. Croix]]; Cortex [Jamie Madrox] |
| Genre | Superhero |
| Pencils | David Yardin |
| Inks | David Yardin |
| Colors | Nathan Fairbairn |
| Notes | U.S. on sale date: 2009-09-16. © 2009 Marvel Characters, Inc. |
| Genre | Superhero |
| Script | Peter David |
| Letters | typeset |
| Notes | Recap of story to date and creator credits. |
| Characters | X-Factor [Darwin [Armando Muñoz]; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller; Ruby Summers; Cyclops [Scott Summers]; Shatterstar; Lenore; Dr. Doom [Victor Von Doom]; Trevor Fitzroy; Winston; Cortex [Jamie Madrox] (villain); Mr. Falcone (villain); Omeganoid Sentinels (villains); Tryp (villain) |
| Synopsis | Siryn and M battle the evil Jamie Madrox duplicate... Cortex. |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Valentine De Landro |
| Inks | Pat Davidson |
| Colors | Jeromy Cox |
| Letters | Cory Petit of Virtual Calligraphy [as VC's Cory Petit] |
| Script | Peter David; Jody LeHeup |
| Letters | typeset |
| Notes | Letters from readers - Andrew M. Grant, Will and Will. |
| Characters | X-Factor [Darwin [Armando Muñoz]; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller |
| Genre | Superhero |
| Pencils | David Yardin (signed) |
| Inks | David Yardin (signed) |
| Colors | Nathan Fairbairn (signed) |
| Letters | typeset |