| Issue | #49 |
| Published | November 2009 |
| Frequency | Monthly |
| Cover Price | 2.99 USD |
| Pages | 36 |
| Editing | Jody LeHeup |
| Notes | U.S. on sale date: 2009-09-30. © 2009 Marvel Characters, Inc. |
| Characters | X-Factor [Darwin [Armando Muñoz]; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller |
| Genre | Superhero |
| Pencils | David Yardin (signed) |
| Inks | David Yardin (signed) |
| Colors | Nathan Fairbairn (signed) |
| Genre | Superhero |
| Script | Peter David |
| Letters | typeset |
| Notes | Recap of story to date, indicia and creator credits. |
| Characters | X-Factor [Darwin [Armando Muñoz]; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller; Ruby Summers; Cyclops [Scott Summers]; Shatterstar; Val Cooper; Lenore; Dr. Doom [Victor Von Doom]; Trevor Fitzroy; Winston; Cortex [Jamie Madrox] (villain); Omeganoid Sentinels (villains) |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Valentine De Landro |
| Inks | Pat Davidson |
| Colors | Jeromy Cox |
| Letters | Cory Petit of Virtual Calligraphy [as VC's Cory Petit] |
| Characters | X-Factor [Darwin [Armando Muñoz]; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller; Shatterstar; Longshot |
| Genre | Superhero |
| Pencils | David Yardin (signed) |
| Inks | David Yardin (signed) |
| Colors | Nathan Fairbairn (signed) |
| Letters | typeset |