| Issue | #50 |
| Published | December 2009 |
| Frequency | Monthly |
| Cover Price | 3.99 USD |
| Pages | 52 |
| Editing | Jody LeHeup |
| Notes | U.S. on sale date: 2009-10-28. © 2009 Marvel Characters, Inc. |
| Characters | X-Factor [Darwin [Armando Muñoz]; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller; Shatterstar; Longshot |
| Genre | Superhero |
| Pencils | David Yardin |
| Inks | David Yardin |
| Colors | Nathan Fairbairn |
| Characters | Dr. Doom [Victor Von Doom] |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Valentine De Landro |
| Inks | Pat Davidson |
| Colors | Jeromy Cox |
| Letters | typeset |
| Notes | Recap of story to date, indicia and creator credits. |
| Characters | X-Factor [Darwin [Armando Muñoz] (cameo); M [Monet St. Croix] (cameo); Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter] (cameo); Siryn [Theresa Rourke Cassidy] (cameo); Strong Guy [Guido Carosella] (cameo)]; Longshot (cameo); Layla Miller; Ruby Summers; Cyclops [Scott Summers]; Shatterstar (cameo); Hecat'e; Dr. Doom [Victor Von Doom]; Trevor Fitzroy; Winston; Cortex [Jamie Madrox] (villain); Omeganoid Sentinels (villains); Anthony Falcone (villain); Mr. Tryp |
| Synopsis | Jamie faces off against Cortex. |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Valentine De Landro |
| Inks | Pat Davidson; Craig Yeung |
| Colors | Jeromy Cox |
| Letters | Cory Petit of Virtual Calligraphy [as VC's Cory Petit] |
| Genre | Fact |
| Letters | typeset |
| Characters | X-Factor [Darwin [Armando Muñoz]; Longshot; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Shatterstar; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller |
| Genre | Superhero |
| Pencils | Esad Ribic |
| Inks | Esad Ribic |
| Colors | Morry Hollowell |
| Letters | typeset |
| Characters | X-Factor [Darwin [Armando Muñoz]; Lonshot; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Shatterstar; Strong Guy [Guido Carosella]]; Franklin Richards; Valeria Richards |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Bing Cansino ?; Marco Santucci ? |
| Inks | Marco Santucci ?; Patrick Piazzalunga ? |
| Colors | Jeromy Cox |
| Letters | Cory Petit of Virtual Calligraphy [as VC's Cory Petit] |
| Notes | Seven page preview of X-Factor (Marvel, 2006 series) #200. |
| Script | Peter David; Jody LeHeup |
| Letters | typeset |
| Notes | Peter David answers letters from readers - Gareth, D in KC, Giovanny and David Bretz. |