| Issue | #496 |
| Published | December 2008 |
| Cover Price | 4.99 USD |
| Pages | 52 |
| Editing | John Ficarra |
| Notes | The tattoos on Alfred's arms are parts of the cover frames used for issues #24-30. ISSN 024 9319 |
| Characters | Alfred D. Neuman |
| Genre | humor |
| Pencils | Mark Fredrickson |
| Inks | Mark Fredrickson |
| Letters | typeset |
| Notes | The tattoos on Alfred's arms are parts of the cover frames used for issues #24-30. ISSN 024 9319 |
| Synopsis | Ad for book from Prima Games. |
| Letters | typeset |
| Notes | On inside front cover. |
| Characters | Alfred E. Neuman; Monroe's dad; George W. Bush |
| Pencils | various |
| Inks | various |
| Letters | typeset |
| Notes | Art is from various places in the magazine. The feature "Feel Or No Feel? Department" is phony and does not actually appear in the issue. |
| Synopsis | Ad for November 11th 2008 DVD releases from Funimation and Toei Animation. |
| Letters | typeset |
| Notes | Occupies bottom halves of first 2 pages of letters pages. |
| Characters | Alfred E. Neuman |
| Synopsis | Letters, photos and fan art. |
| Script | John Ficarra; Nathaniel Ritter; Zachary Weiner; Josh Kerdell; Billy Hornby; Kevin Lagowski; John Stroud |
| Pencils | Bill Bramhall; ?; ? (photo) |
| Inks | Bill Bramhall; ?; ? (photo) |
| Letters | typeset |
| Letters | typeset |
| Characters | Alfred E. Neuman; Bill Clinton |
| Synopsis | House ad for MAD Magazine Poster Book and MAD About Politics pop-up book. |
| Letters | typeset |
| Characters | Bill Gates; Jerry Seinfeld; Melvin; Jenkins; Lil Wayne |
| Synopsis | Various short satires of pop culture. |
| Genre | humor |
| Script | various |
| Pencils | various |
| Inks | various |
| Letters | typeset |
| Notes | Contributors (roles unknown) include: Charles Akins; Greg Benson; Dick DeBartolo; Desmond Devlin; J. C. Duffy; Darren Johnson; Jeff Kruse; Kevin Pope; Tom Lambert; Tom Richmond; Ward Sutton; Rick Tulka |
| Synopsis | Ad for book by Jake Wizner from Random House. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Notes | On 2nd page of Fundalini Pages. |
| Characters | Black Spy; White Spy |
| Synopsis | Ad for merchandise from the International Spy Museum. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Notes | On 4th page of Fundalini Pages. |
| Characters | Carl "Yung Carl" Pringle; Carl's parents; Carl's grandmother; Lil Wayne; Bill O'Reilly; Ja Rule; Weird Al Yankovic; Tupac; JMJ; Big Pun; Notorious B.I.G. |
| Synopsis | Satire on meteoric rise and fall of rap and hip hop music stars. |
| Genre | satire |
| Script | Desmond Devlin |
| Pencils | Hermann Mejia |
| Inks | Hermann Mejia |
| Letters | typeset |
| Characters | Deal Or No Deal Models |
| Synopsis | Phony captions of what the models are thinking when standing on stage. |
| Script | Ross Garmil; Matthew A. Cohen |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Characters | Cooter Smiff; Abner Smiff; Mr. Smiff; Zeus |
| Synopsis | Story of a Clydesdale racing horse and a family that duct-taped dead jockeys to him. |
| Genre | humor |
| Script | Brian McConnachie |
| Pencils | Leonardo Rodriguez |
| Inks | Leonardo Rodriguez |
| Letters | typeset |
| Notes | Fifth in a series of MAD's Inspirational Animal Stories. |
| Synopsis | A look at some ridiculous things that could happen while traveling the country by car. |
| Genre | humor |
| Script | Sergio Aragones |
| Pencils | Sergio Aragones |
| Synopsis | Ad for game from Midway Amusement Games, LLC. |
| Letters | typeset |
| Notes | Title given is on page 2. |
| Characters | Monroe; Monroe's mother; Monroe's father; Monroe's grandfather; Eugene |
| Synopsis | Monroe's family gets caught in a hurricane because they miss the evacuation notice, and their home is spared from destruction. |
| Genre | humor |
| Script | Anthony Barbieri |
| Pencils | Tom Fowler |
| Inks | Tom Fowler |
| Colors | Carl Peterson |
| Synopsis | Ad for the following MAD books: Spy Vs. Spy 2; MAD About Star Wars; The MAD War on Bush; The Completely MAD Don Martin. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Synopsis | Everyday quotes too honest for anyone to actually say. |
| Genre | humor |
| Script | Darren Johnson |
| Pencils | Tom Bunk |
| Inks | Tom Bunk |
| Letters | typeset |
| Characters | Black Spy; White Spy |
| Synopsis | In the first cartoon, the Black Spy tricks the White Spy into a trap. In the second cartoon, the White Spy outsmarts the Black Spy with a fake rocket. |
| Genre | humor |
| Script | Peter Kuper |
| Pencils | Peter Kuper |
| Inks | Peter Kuper |
| Notes | Two cartoons. |
| Characters | Tad; Mr. Davis; Zac Efron; Jodie Foster; Mrs. Winter; Aquaman; Sub-Mariner; Chuck; Beth |
| Synopsis | Tad joins the debate team and screws up his first (and last) debate by arguing for the opposing team. |
| Genre | humor |
| Script | Tim Carvell |
| Pencils | ?; ? (photo) |
| Inks | ?; ? (photo) |
| Colors | ?; ? (photo) |
| Letters | typeset |
| Characters | Dave Berg; Roger Kaputnik |
| Synopsis | New gags written for Dave Berg's drawings. |
| Genre | humor |
| Script | Dave Berg (original); ? (revised) |
| Pencils | Dave Berg |
| Inks | Dave Berg |
| Letters | typeset |
| Notes | The new gag writer is not credited. |
| Reprinted | From Mad (EC, 1952 Series) #? |
| Characters | George Bush; Brownie |
| Synopsis | Events of the Bush administration explained as parodies of children's books. |
| Genre | satire |
| Script | David Shayne |
| Pencils | Gary Hallgren |
| Inks | Gary Hallgren |
| Letters | typeset |
| Notes | Three books: The Talking Tree (by Smell Silverstein), The Little Engineer That Couldn't (by Snotty Griper), Failing Up (by Smell Silverstein). Several other books mentioned. |
| Synopsis | Ad for manga books from Viz Media. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Synopsis | Answer is: maternity ward. |
| Genre | humor |
| Script | Al Jaffee (signed) |
| Pencils | Al Jaffee (signed) |
| Inks | Al Jaffee (signed) |
| Letters | typeset |
| Notes | Inside back cover. |
| Genre | gags |
| Script | Sergio Aragones |
| Pencils | Sergio Aragones |
| Inks | Sergio Aragones |
| Notes | Gags appear on 20 different pages. |
| Synopsis | Ad for game from Midway Studios. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | typeset |
| Notes | Back cover. |