| Issue | #200 |
| Published | February 2010 |
| Frequency | Monthly |
| Cover Price | 4.99 USD |
| Pages | 108 |
| Editing | Jody LeHeup |
| Notes | U.S. on sale date: 2009-12-16. © 2009 Marvel Characters, Inc. |
| Characters | X-Factor [Darwin [Armando Muñoz]; Longshot; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Shatterstar; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller |
| Genre | Superhero |
| Pencils | Esad Ribic |
| Inks | Esad Ribic |
| Colors | Morry Hollowell |
| Notes | Wraparound cover |
| Characters | X-Factor [Darwin [Armando Muñoz]; Longshot; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Shatterstar; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller |
| Genre | Superhero |
| Pencils | David Yardin |
| Inks | David Yardin |
| Colors | David Yardin ? |
| Notes | 1:15 variant cover |
| Characters | X-Factor [Darwin [Armando Muñoz]; Longshot; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Shatterstar; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller |
| Genre | Superhero |
| Pencils | Kevin Maguire |
| Inks | Kevin Maguire |
| Colors | Nathan Fairbairn |
| Notes | 1:25 variant cover |
| Script | Peter David |
| Letters | typeset |
| Notes | Recap of story to date, indicia and creator credits. |
| Characters | X-Factor [Darwin [Armando Muñoz]; Longshot; M [Monet St. Croix]; Multiple Man [Jamie Madrox]; Rictor [Julio Esteban Richter]; Shatterstar; Siryn [Theresa Rourke Cassidy]; Strong Guy [Guido Carosella]]; Layla Miller (cameo); Fantastic Four [Invisible Woman [Sue Richards]; Mr. Fantastic [Reed Richards]; Thing [Ben Grimm]]; Franklin Richards; Valeria Richards; Deadpool [Wade Wilson] (voice only); Val Cooper |
| Synopsis | X-Factor takes on a case for Valeria and Franklin Richards... find the Invisible Woman. |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Bing Cansino; Marco Santucci |
| Inks | Marco Santucci; Patrick Piazzalunga |
| Colors | Jeromy Cox |
| Letters | Cory Petit of Virtual Calligraphy [as VC's Cory Petit] |
| Characters | Siryn [Theresa Rourke Cassidy]; Father John Maddox (Jamie's duplicate) |
| Synopsis | Father John helps Siryn deal with her grief. |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Karl Moline |
| Inks | Rich Magyar |
| Colors | Jeromy Cox |
| Letters | Cory Petit of Virtual Calligraphy [as VC's Cory Petit] |
| Genre | Superhero |
| Notes | Reprint of covers from X-Factor (Marvel, 1986 series) #1-149 and X-Factor (Marvel, 2006 series) #1-50 & 200. Ryan Devall (production) and Spring Hoteling (design). |
| Characters | Multiple Man [Jamie Madrox]; Father John Maddox (Jamie's duplicate); Sean (a baby; Jamie's duplicate) |
| Genre | Superhero |
| Pencils | Kerry Gammill; Pablo Raimondi; Mike McKone; Larry Stroman; Jan Duursema; Jeff Matsuda; Aaron Lopresti; Dennis Calero |
| Letters | typeset |
| Characters | Layla Miller |
| Genre | Superhero |
| Pencils | Olivier Coipel; Valentine De Landro |
| Letters | typeset |
| Characters | Darwin [Armando Muñoz] |
| Genre | Superhero |
| Pencils | Marc Silvestri; Pete Woods; Billy Tan |
| Letters | typeset |
| Characters | Siryn [Theresa Rourke Cassidy] |
| Genre | Superhero |
| Pencils | Ryan Sook; Steve Leialoha; Rob Liefeld; Adam Pollina |
| Letters | typeset |
| Characters | M [Monet St. Croix; also as Penance]; Twins [Claudette St. Croix; Nicole St. Croix] |
| Genre | Superhero |
| Pencils | Ryan Sook; Chris Bachalo; Terry Dodson; Aaron Lopresti; Art Adams; Steve Pugh |
| Letters | typeset |
| Characters | Strong Guy [Guido Carosella] |
| Genre | Superhero |
| Pencils | Jeff Matsuda; Dennis Calero; Jan Duursema; Chris Batista; Andy Smith |
| Letters | typeset |
| Characters | Rictor [Julio Esteban Richter] |
| Genre | Superhero |
| Pencils | Ryan Sook; Tony Daniel; Bret Blevins |
| Letters | typeset |
| Characters | Longshot |
| Genre | Superhero |
| Pencils | Art Adams; Paul Pelletier |
| Letters | typeset |
| Characters | Shatterstar [Gaveedra-Seven] |
| Genre | Superhero |
| Pencils | Marco Santucci; Scott S. Miller; Rob Liefeld; Joe Jusko; Frank Cirocco |
| Letters | typeset |
| Genre | Superhero |
| Pencils | David Lloyd |
| Inks | David Lloyd |
| Colors | Brian Reber |
| Editing | Andy Schmidt; Nicole Wiley (assistant) |
| Reprinted | from Madrox (Marvel, 2004 series) #1 (November 2004) |
| Characters | Multiple Man [Jamie Madrox]; Wolfsbane [Rahne Sinclair]; Strong Guy [Guido Carosella] |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Pablo Raimondi |
| Inks | Drew Hennessy |
| Colors | Brian Reber |
| Letters | Cory Petit of Virtual Calligraphy [as VC's Cory Petit] |
| Editing | Andy Schmidt; Nicole Wiley (assistant) |
| Reprinted | from Madrox (Marvel, 2004 series) #1 (November 2004) |
| Characters | Multiple Man [Jamie Madrox]; Mr. Fantastic [Reed Richards]; Dr. Doom [Victor Von Doom]; Layla Miller |
| Genre | Superhero |
| Pencils | David Yardin |
| Inks | David Yardin |
| Letters | typeset |