| Issue | #578 |
| Published | June 2010 |
| Frequency | monthly |
| Cover Price | 2.99 USD |
| Pages | 36 |
| Editing | Tom Brevoort; Lauren Sankovitch (associate) |
| Characters | Mr. Fantastic; the Thing; Human Torch; Annihilus |
| Genre | super-hero |
| Script | Jonathan Hickman |
| Pencils | Alan Davis |
| Inks | Mark Farmer |
| Colors | Javier Rodriguez |
| Letters | typeset |
| Synopsis | An advertisement for Random House Children's Books' _Games and Puzzles from the Tree House_. |
| Notes | Upper half of inside front cover. |
| Synopsis | An advertisement for Ron Roy's "Calendar Mysteries" book series. |
| Notes | lower half of inside front cover |
| Letters | typeset |
| Characters | Human Torch [Johnny Storm]; Valeria Richards; Andromeda Attumasen; Mr. Fantastic |
| Synopsis | Johnny inadvertently lets a group of Annihilus's assassins into the Negative Zone, where they kill a group of Blastaar's people. The city of Old Atlantis is moved to the surface of the Antarctic. |
| Genre | super-hero |
| Script | Jonathan Hickman |
| Pencils | Dale Eaglesham |
| Colors | Paul Mounts |
| Letters | Rus Wooton [as VC's Rus Wooton] |
| Synopsis | An advertisement for Iron Man statues from Kotobukiya. |
| Notes | This advertisement is between pages 3 and 4 of the Fantastic Four story. |
| Synopsis | An advertisement for the the theatrical release of the Marvel Studios film, "Iron Man 2". |
| Notes | This advertisement is between page 6 of the Fantastic Four story and the Thor and the Warriors Four promotional. |
| Synopsis | An in-house promotional advertisement for Thor and the Warriors Four (Marvel, 2010 series) #2. |
| Notes | This advertisement is between the Iron Man 2 advertisement and page 7 of the Fantastic Four story. |
| Synopsis | An advertisement for children's clothing from Kids Headquarters, featuring licensed Marvel characters. |
| Notes | This advertisement is between pages 7 and 8 of the Fantastic Four story. |
| Synopsis | An advertisement for Jakks Pacific professional wrestling action figures. |
| Notes | This advertisement is between pages 10 and 11 of the Fantastic Four story. |
| Synopsis | An advertisement for Sherwood candies featuring Spider-Man. |
| Notes | This advertisement is on the upper half of the page between page 15 of the Fantastic Four story and the Marvel Super Hero Squad promotional. |
| Synopsis | An in-house promotional advertisement for Marvel Super Hero Squad (Marvel, 2010 series) #5. |
| Notes | This advertisement is on the lower half of the page between the Spider-Sense candy advertisement and page 16 of the Fantastic Four story. |
| Synopsis | An in-house promotional advertisement for Secret Avengers (Marvel, 2010 series). |
| Notes | This advertisement is between pages 18 and 19 of the Fantastic Four story. |
| Synopsis | An in-house promotional advertisement for Siege (Marvel, 2010 series) #4. |
| Notes | This advertisement is between pages 22 and 23 of the Fantastic Four story. |
| Synopsis | Letters of comment from Andrew J. Shaw; Mason Tripp; Chip Snyder; Sais Ruiz Reyes; and Ed Kaerva. |
| Script | Jonathan Hickman |
| Letters | typeset |
| Notes | This letter column follows the final page of the Fantastic Four story. |
| Synopsis | An advertisement for Jay Franco's children's bedclothes, featuring Iron Man. |
| Notes | inside back cover |
| Synopsis | An advertisement for the Cartoon Network's animated series, "Generator Rex." |
| Notes | back cover |