| Issue | #20 |
| Published | June 2006 |
| Cover Price | 2.25 USD |
| Pages | 36 |
| Editing | Joan Hilty; Rachel Gluckstern (Assistant Editor) |
| Characters | Powerpuff Girls [Buttercup; Bubbles; Blossom]; Mojo Jojo; Dexter; Ed; Edd; Eddy |
| Genre | children |
| Pencils | Robert Pope (signed) |
| Inks | Robert Pope |
| Characters | Powerpuff Girls [Blossom; Buttercup; Bubbles]; Mojo Jojo; Gangreen Gang [Ace; Big Billy; Snake; Grubber; Li'l Arturo]; Professor Utonium |
| Synopsis | The girls clean up Townsville when Mojo Jojo and the Gangreens make a mess. |
| Genre | children; superhero |
| Script | Robbie Busch |
| Pencils | Ricardo Garcia-Fuentes |
| Inks | Mike DeCarlo |
| Colors | Heroic Age |
| Letters | Travis Lanham |
| Characters | Dexter; Dad (cameo) |
| Synopsis | Dexter gives a basic lesson in DNA theory. |
| Genre | children; science fiction |
| Script | John Rozum |
| Pencils | Matthew I. Jenkins |
| Inks | Dan Davis |
| Colors | Heroic Age |
| Letters | Travis Lanham |
| Characters | Ed; Edd; Eddy; Kevin; Jimmy; Sarah |
| Synopsis | The boys play a game of Lizards and Wizards. |
| Genre | children |
| Script | Robbie Busch |
| Pencils | Joel Dickie |
| Inks | Angus Bungay |
| Colors | Heroic Age |
| Letters | Travis Lanham |
| Characters | Powerpuff Girls [Blossom; Bubbles; Buttercup] |
| Script | ? [as Johnny DC] |
| Pencils | ? (illo) |
| Inks | ? (illo) |
| Colors | ? (illo) |
| Letters | typeset |
| Notes | Art and letters submitted by Haba Abdeirazek; Violet Dawn Cumberland; Kristiana Watson; Sophia Grosshauser; Colin J. Reboy; Emma Johnston |