| Issue | #1 |
| Published | [March] 2006 |
| Cover Price | 2.99 USD |
| Pages | 36 |
| Editing | ? |
| Notes | Wraparound Cover. |
| Characters | Painkiller Jane [Jane Vasco] |
| Genre | Superhero |
| Pencils | Joe Quesda |
| Inks | Jimmy Palmiotti |
| Notes | Wraparound Cover. |
| Characters | Painkiller Jane [Jane Vasco] |
| Genre | Superhero |
| Pencils | Amanda Conner |
| Inks | Amanda Conner |
| Characters | Painkiller Jane [Jane Vasco] |
| Genre | Superhero |
| Pencils | Lee Moder |
| Inks | Lee Moder |
| Characters | Painkiller Jane [Jane Vasco] |
| Genre | Superhero |
| Pencils | Billy Tan |
| Inks | Billy Tan |
| Characters | Painkiller Jane [Jane Vasco] |
| Genre | Superhero |
| Pencils | Adam Hughes |
| Inks | Adam Hughes |
| Notes | Retailer Incentive 1 in 10 cover. |
| Characters | Painkiller Jane [Jane Vasco]; Maureen Fernandez; Dr. Seth; Johnny Fitzgerald |
| Synopsis | Painkiller Jane clears out Johnny Fitzgerald's house of horrors only to discover that things go deeper than she believed. |
| Genre | Superhero |
| Script | Joe Quesada (Plot); Jimmy Palmiotti (Plot & Script) |
| Pencils | Lee Moder |
| Inks | Lee Moder |
| Colors | Pilvi Kuusela (of Imaginary Friends Studio) |
| Letters | Simon Bowland |
| Characters | George Perez (Photo) |
| Synopsis | Information on the book "Storyteller" by Christopher Lawrence on George Perez. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Colors | ? (photo) |
| Letters | Typeset |