| Issue | #21 |
| Published | July 2006 |
| Cover Price | 2.25 USD |
| Pages | 36 |
| Editing | Joan Hilty; Rachel Gluckstern (Assistant Editor) |
| Characters | Powerpuff Girls [Bubbles; Blossom; Buttercup]; Professor Utonium; Mojo Jojo; Johnny Bravo; Grim; Billy; Mandy |
| Genre | children |
| Pencils | Robert Pope (signed) |
| Inks | Robert Pope (signed) |
| Characters | Powerpuff Girls [Buttercup; Bubbles; Blossom]; Mojo Jojo; Mayor; Professor Utonium |
| Synopsis | Mojo Jojo sues the city of Townsville, and as part of the settlement, he gets to move in with Professor Utonium and the girls in order to share the lab. |
| Genre | children |
| Script | Scott Roberts |
| Pencils | Cindy Morrow |
| Inks | Mike DeCarlo |
| Colors | Heroic Age |
| Letters | Travis Lanham |
| Characters | Johnny Bravo; Pops |
| Synopsis | Pops should never have left Johnny to take care of his fish for the weekend. |
| Genre | children |
| Script | Jim Alexander |
| Pencils | Mike DeCarlo |
| Inks | Mike DeCarlo |
| Colors | Heroic Age |
| Letters | Travis Lanham |
| Characters | Grim; Billy; Mandy |
| Synopsis | Grim is committed to an asylum when they don't believe he is really the Grim Reaper. |
| Genre | children |
| Script | Sholly Fisch |
| Pencils | Robert Pope |
| Inks | Phil Moy |
| Colors | Heroic Age |
| Letters | Travis Lanham |
| Characters | Powerpuff Girls [Buttercup; Blossom; Bubbles] |
| Script | ? [as Johnny DC] |
| Pencils | ? (illo) |
| Inks | ? (illo) |
| Colors | ? (illo) |
| Letters | typeset |
| Notes | Art and letters submitted by Addie Wylie; Jasmine Goldstein; Rebecca Shapiro; Rocio Dunlap; Lauren Guidry. |