| Issue | #15 |
| Published | July 2006 |
| Cover Price | $2.99/$4.25 CAD |
| Pages | 36 |
| Editing | Andy Schmidt; Caroline McGraw (assistant) |
| Notes | Final issue |
| Characters | Spider-Man |
| Genre | Superhero |
| Pencils | Jay Anacleto |
| Inks | Jay Anacleto |
| Colors | Jay Anacleto |
| Notes | Final issue |
| Characters | Spider-Man; Curt Connors; Martha Connors |
| Pencils | Klaus Janson; Adam DeKraker |
| Inks | Klaus Janson; Cam Smith |
| Colors | Steve Buccellato; A. Street of Stotocolor |
| Letters | Typeset |
| Notes | Story credits and creator biographies. |
| Characters | Spider-Man [Peter Parker]; Ethan |
| Synopsis | Comics legend, Klaus Janson tells a personal story delving into the effects on a child who is raised by one of Spider-Man’s foes. [per solicitation] |
| Genre | Superhero |
| Script | Klaus Janson |
| Pencils | Klaus Janson |
| Inks | Klaus Janson |
| Colors | Steve Buccellato |
| Letters | David Sharpe |
| Characters | Spider-Man [Peter Parker]; Lizard [Curt Connors]; Martha Connors; Billy Connors |
| Synopsis | Merrill Hagan tells a story featuring the Lizard and his wife. How does a woman cope with being married to a man who must remain calm at all times or he’ll turn into a giant green beast? Can she possible still love him if she must never do or say anything that could set him off? [per solicitation] |
| Genre | Superhero |
| Script | Merrill Hagan |
| Pencils | Adam DeKraker |
| Inks | Cam Smith |
| Colors | A. Street of Stotocolor |
| Letters | David Sharpe |