| Issue | #4 |
| Published | December 2006 |
| Cover Price | 3.99 USD |
| Pages | 36 |
| Editing | Chris Ryall |
| Notes | Cover #4-A |
| Characters | Spike |
| Genre | superhero; occult |
| Pencils | Franco Urru |
| Inks | Franco Urru |
| Colors | Paolo Maddaleni |
| Notes | Cover #4-A |
| Characters | Spike |
| Genre | superhero; occult |
| Pencils | Matt Busch |
| Inks | Matt Busch |
| Colors | Paolo Maddaleni |
| Editing | Chris Ryal |
| Notes | Cover #4-B |
| Characters | Spike |
| Genre | superhero; occult |
| Pencils | ? [Photo Cover] |
| Inks | ? [Photo Cover] |
| Colors | ? [Photo Cover] |
| Editing | Chris Ryall |
| Notes | Retailer Incentive Photo Cover |
| Characters | Spike; Lorne; Miss Malposo; Dr. Thilbault; Mah Zinn (Chief Administrator); Marv [Werewolf]; Biv; Betta George; Beck; Wiseau (Vampire) |
| Synopsis | After contacting Lorne, Spike begins his escape from Mosiac. |
| Genre | superhero; occult |
| Script | Brian Lynch |
| Pencils | Franco Urru |
| Inks | Franco Urru |
| Colors | Paolo Maddaleni |
| Letters | Neil Uyetake |
| Synopsis | Interview about the new Star Trek series from IDW. |
| Letters | Typeset |
| Synopsis | Preview of the upcoming Desperadoes mini-series Buffalo Dreams. |
| Genre | Western |
| Script | Jeff Mariotte |
| Pencils | Alberto Dose |
| Inks | Alberto Dose |