| Issue | #253 |
| Published | September 1991 |
| Cover Price | 1.50 USD; 1.80 CAD |
| Pages | 52 |
| Editing | Jim Salicrup; Dan Cuddy (assistant) |
| Characters | Spider-Man; Morbius |
| Genre | Superhero |
| Pencils | Jean Giraud [signed as Moebius] |
| Inks | Sylvain (signed) |
| Characters | Spider-Man [Peter Parker]; Gwen Stacy; Aunt May Parker; J. Jonah Jameson; Robbie Robertson; Lizard [Curt Connors]; Morbius [Michael Morbius] (origin); Nikos (flashback, dies); Martine (flashback); Syd; Leo |
| Synopsis | Spider-Man versus Morbius versus the Lizard and we learn the origin of Morbius. Plus, Doc Connors prepares a serum that cures Spidey of his six-arm problem. |
| Genre | Superhero |
| Script | Roy Thomas |
| Pencils | Gil Kane |
| Inks | Frank Giacoia |
| Letters | Art Simek |
| Editing | Stan Lee (original) |
| Reprinted | from Amazing Spider-Man, The (Marvel, 1963 series) #102 (November 1971) |
| Script | Stan Lee; ? |
| Letters | typeset |
| Notes | Stan Lee talks about Comic Book Con. Miscellaneous Marvel news items. |
| Characters | Spider-Man |
| Genre | Superhero |
| Pencils | John Romita |
| Inks | Frank Giacoia |
| Editing | Stan Lee (original) |
| Reprinted | from Amazing Spider-Man, The (Marvel, 1963 series) #100 (September 1971) |
| Characters | Spider-Man; Morbius |
| Genre | Superhero |
| Pencils | Gil Kane |
| Inks | John Romita |
| Editing | Stan Lee (original) |
| Reprinted | from Amazing Spider-Man, The (Marvel, 1963 series) #101 (October 1971) |
| Characters | Spider-Man; Morbius; Lizard |
| Genre | Superhero |
| Pencils | Gil Kane |
| Inks | Frank Giacoia |
| Editing | Stan Lee (original) |
| Reprinted | from Amazing Spider-Man, The (Marvel, 1963 series) #102 (November 1971) |