| Issue | #4 |
| Published | 1988 |
| Cover Price | 1.75 USD; 2.25 CAD |
| Pages | 68 |
| Editing | Jim Salicrup |
| Characters | Spider-Man; Slug |
| Genre | Superhero |
| Pencils | Alex Saviuk (signed) |
| Inks | John Romita, Sr. (signed) |
| Characters | Spider-Man [Peter Parker]; Mary Jane Watson-Parker; Man-Thing [Ted Sallis]; Poison [Cecilia Cardinale]; Carlos Cardinale; Doyle Denby; Villains: High Evolutionary [Herbert Edgar Wyndham]; Kingpin [Wilson Fisk]; Slug [Ulyssus S. Luggman]; Mr. Baccar; Mr. Santo |
| Synopsis | The Evolutionary War continues and the introduction of Poison. |
| Genre | Superhero |
| Script | Steve Gerber |
| Pencils | Cynthia Martin |
| Inks | Cynthia Martin |
| Colors | Janet Jackson |
| Letters | Rick Parker |
| Notes | Story continued from X-Men Annual (1990) #12 and story continues in West Coast Avengers Annual (1989) #3. |
| Characters | Poison [Cecilia Cardinale] |
| Synopsis | The origin of Poison. |
| Genre | Superhero |
| Script | Steve Gerber |
| Pencils | Alex Saviuk |
| Inks | Alex Saviuk |
| Colors | Janet Jackson |
| Letters | Rick Parker |
| Characters | Spider-Man [Peter Parker] |
| Genre | Superhero |
| Pencils | Arthur Adams |
| Inks | Arthur Adams |
| Notes | Recap of the saga of the alien costume and pin-up. |
| Characters | Spider-Man [Peter Parker]; Mary Jane Watson-Parker |
| Genre | Superhero |
| Pencils | John Romita, Sr. |
| Inks | John Romita, Jr. |
| Notes | Recap of the wedding of Peter and Mary Jane and pin-up. |
| Characters | Spider-Man [Peter Parker; black costume]; Kraven the Hunter |
| Genre | Superhero |
| Pencils | Mike Zeck |
| Inks | Bob McLeod |
| Notes | Recap of the Kraven saga and pin-up. |
| Characters | Spider-Man [Peter Parker; black costume] |
| Genre | Superhero |
| Pencils | Mike Zeck |
| Inks | Joe Rubinstein |
| Notes | More recap on the Kraven saga and the hunt for Vermin and a pin-up. |
| Characters | Spider-Man [Peter Parker; black costume] |
| Genre | Superhero |
| Pencils | Mike Harris |
| Inks | Mike Harris |
| Notes | More recap on the Kraven saga and a pin-up. |
| Characters | Spider-Man [Peter Parker; black costume]; Kingpin [Wilson Fisk] |
| Genre | Superhero |
| Pencils | Cynthia Martin |
| Inks | Cynthia Martin |
| Notes | Recap of Peter's time in an asylum run by the Kingpin and a pin-up. |
| Characters | Spider-Man [Peter Parker] |
| Genre | Superhero |
| Pencils | Joe Brozowski |
| Inks | Joe Brozowski |
| Notes | Recap of Spider-Man saving Manhattan from Doctor Octopus and nuclear destruction and a pin-up. |
| Characters | Spider-Man [Peter Parker] |
| Genre | Superhero |
| Pencils | Todd McFarlane |
| Inks | Todd McFarlane |
| Notes | Recap of Amazing Spider-Man #300 and the introduction of Venom. |
| Characters | Spider-Man [Peter Parker]; Black Cat [Felicia Hardy] |
| Genre | Superhero |
| Notes | Recap of the rest of the year and a pin-up. |
| Characters | High Evolutionary [Herbert Edgar Wyndham]; Hystrix (deceased); Bova; Doctor Jonathan Drew; Jessica Drew [baby; Spider-Woman]; Robert Frank; Madeline Frank (dies in childbirth); Django Maximoff; Marya Maximoff; Wanda Maximoff [baby; Scarlet Witch]; Pietro Maximoff [baby; Quicksilver] |
| Genre | Superhero |
| Script | Mark Gruenwald |
| Pencils | Ron Lim |
| Inks | Tony DeZuniga |
| Colors | Gregory Wright |
| Letters | Ken Lopez |
| Notes | Story continued from X-Men Annual (1990) #12 and story continues in West Coast Avengers Annual (1989) #3. |