| Issue | #225 |
| Published | June-July 1974 |
| Frequency | bi-monthly |
| Cover Price | 0.60 USD |
| Pages | 100 |
| Editing | Joe Orlando |
| Pencils | Luis Dominguez; ? |
| Inks | Luis Dominguez; ? |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Characters | Cain |
| Synopsis | intro page |
| Pencils | Bernie Wrightson |
| Inks | Bernie Wrightson |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Characters | Cain (host) |
| Genre | horror |
| Script | Jack Oleck |
| Pencils | Alfredo Alcala |
| Inks | Alfredo Alcala |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Characters | Cain (host - added to original story) |
| Genre | occult |
| Pencils | Jack Kirby |
| Inks | Jack Kirby |
| Editing | Whitney Ellsworth (original editor) |
| Reprinted | from House of Secrets (DC, 1956 series) #4 (May-June 1957) |
| Characters | Cain (host) |
| Genre | horror |
| Script | Michael Fleisher; Russell Carley (Script Continuity) |
| Pencils | Frank Thorne |
| Inks | Frank Thorne |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Characters | Cain (host - added to original story); Rachel MacIntyre; Rachel's Father; Blair; Frances (Housekeeper); Jamie; Fred; Maggie; Alfie; Adrienne |
| Synopsis | After Rachel's father dies, Rachel moves in with her cousin's family who are all afflicted with a mental illness that her father was trying to create an antidote for. |
| Genre | horror; romance |
| Pencils | Don Heck |
| Inks | Don Heck |
| Notes | The original job number was D-225. |
| Reprinted | from Sinister House of Secret Love (DC, 1971 series) #1 (October-November 1971) |
| Genre | horror |
| Script | Jack Oleck |
| Pencils | Alex Nino |
| Inks | Alex Nino |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Characters | Phantom Stranger; Cain (host - added to original story) |
| Genre | occult |
| Script | John Broome |
| Pencils | Murphy Anderson |
| Inks | Joe Giella |
| Editing | Whitney Ellsworth (original editor) |
| Notes | Corrected writer and inker credits from Arthur Lortie via Phantom Stranger, The (DC, 1952 series) #4 (March 25, 2006). Original writer credit given to Sy Barry. Original inker credit given to Murphy Anderson. |
| Reprinted | from Phantom Stranger, The (DC, 1952 series) #4 (February-March 1953) |
| Characters | Spectre; Cain (host) |
| Genre | occult; superhero |
| Script | Mark Hanerfeld |
| Pencils | Jack Sparling |
| Inks | Jack Sparling |
| Editing | Dick Giordano (original editor) |
| Reprinted | from Spectre, The (DC, 1967 series) #9 (March-April 1969) |
| Characters | Cain (host) |
| Genre | horror |
| Script | George Kashdan ; David Kasakove (story idea) |
| Pencils | E. R. Cruz |
| Inks | E. R. Cruz |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Characters | Cain (host) |
| Script | Bob Rozakis (puzzle construction) |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Synopsis | gag cartoons |
| Genre | humor |
| Pencils | Sergio Aragones |
| Inks | Sergio Aragones |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Synopsis | Palmistry demonstration. |
| Pencils | Sergio Aragones |
| Inks | Sergio Aragones |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Synopsis | gag cartoons |
| Genre | humor |
| Pencils | Sergio Aragones |
| Inks | Sergio Aragones |
| Reprinted | in Showcase Presents: The House of Mystery (DC, 2006 series) #3 |
| Letters | typeset |
| Notes | letters submitted by John Drake; Steve Gilary; Tom Braden; Jim Calogens; Greg Harried; Danny Richards; Lee Purvis; Richard Lee Sullivan; Craig Douglas; Bill Corron; Valarie Lee; Ken Hamilton; G.H. |