| Issue | #25 |
| Published | May 1961 |
| Frequency | monthly, with the exception of Mar, June, Sept, Dec |
| Cover Price | 0.10 USD |
| Pages | 36 |
| Editing | Mort Weisinger |
| Characters | Lois Lane; Superman; Lana Lang |
| Genre | superhero |
| Pencils | Kurt Schaffenberger |
| Inks | Kurt Schaffenberger |
| Letters | Ira Schnapp |
| Pencils | ? (illustrations) |
| Inks | ? (illustrations) |
| Letters | Ira Schnapp |
| Notes | inside front cover; house ad promoting DC's still-ten-cent comics |
| Characters | Lois Lane; Superman; Lana Lang; Jimmy Olsen; President John Fitzgerald Kennedy (cameo); Jacqueline Kennedy (cameo) |
| Synopsis | Lois finds that she can no longer lead a normal life after marrying the Man of Steel. |
| Genre | superhero |
| Script | Jerry Siegel |
| Pencils | Kurt Schaffenberger |
| Inks | Kurt Schaffenberger |
| Notes | "Imaginary Story, fourth of a series." Writer credit from reprint. |
| Reprinted | in Best of DC, The (DC, 1979 series) #19 (December 1981) |
| Synopsis | Children are lectured about the frequency of accidents injuring the eye and how to prevent them. |
| Genre | fact |
| Script | Jack Schiff |
| Pencils | Bernard Baily |
| Inks | Bernard Baily |
| Letters | Ira Schnapp |
| Notes | published in cooperation with the National Social Welfare Assembly |
| Characters | Professor Eureka; Minerva |
| Genre | humor |
| Script | Henry Boltinoff |
| Pencils | Henry Boltinoff |
| Inks | Henry Boltinoff |
| Letters | Henry Boltinoff |
| Notes | First line and reprint data from Arthur Lortie, added August 2006. |
| Reprinted | in House of Secrets (DC, 1956 series) #74 (September-October 1965) |
| Characters | Lois Lane; Superman [also appears as Clark Kent]; Sandra Thorne; Jacques of Paris; Rita; Professor Boone; Kurt |
| Synopsis | Lois discovers a blackmail ring. |
| Genre | superhero |
| Script | Robert Bernstein |
| Pencils | Kurt Schaffenberger |
| Inks | Kurt Schaffenberger |
| Notes | writer identification by Martin O'Hearn |
| Reprinted | in Superman's Girl Friend, Lois Lane (DC, 1958 series) #77 (October 1967) |
| Characters | Tricksy |
| Genre | humor |
| Script | Henry Boltinoff |
| Pencils | Henry Boltinoff (signed) |
| Inks | Henry Boltinoff |
| Letters | Henry Boltinoff |
| Script | Mort Weisinger ? |
| Pencils | Al Plastino ? (logo illustration) |
| Inks | ? (logo illustration) |
| Colors | ? (logo illustration) |
| Letters | typeset |
| Notes | Letters submitted by Lynda McCall; Carol Springer; Stanley Powell; John Pippin; Carl Malcolm McKinney; Maybelle Hobson; Jerry Waring |
| Characters | Lois Lane; Superman [also appears as Clark Kent]; Perry White; Jimmy Olsen |
| Synopsis | Following a minor auto accident, Lois takes on the personalities of Florence Nightingale, Betsy Ross, and Queen Isabella and Superman has to keep her out of trouble. |
| Genre | superhero |
| Pencils | John Forte |
| Inks | John Forte |