| Issue | #4 |
| Published | February 1974 |
| Cover Price | 0.75 USD |
| Pages | 76 |
| Editing | Roy Thomas |
| Genre | Occult |
| Pencils | Frank Brunner |
| Inks | Frank Brunner |
| Reprinted | In Essential Monster of Frankenstein (Marvel, 2004 series) #1 |
| Script | Tony Isabella |
| Pencils | Pablo Marcos |
| Inks | Pablo Marcos |
| Notes | inside front cover |
| Reprinted | In Monsters Unleashed #10 (February 1975) |
| Characters | Derek McDowell; Frankenstein Monster; Dr. Wallach |
| Synopsis | Derek removes the brain from the Frankenstein Monster and replaces it with the brain from Dr. Wallach. |
| Genre | Monster |
| Script | Gary Friedrich |
| Pencils | John Buscema |
| Inks | Syd Shores; Win Mortimer |
| Reprinted | In Essential Monster of Frankenstein (Marvel, 2004 series) #1 |
| Genre | Occult |
| Script | Stan Lee |
| Pencils | Gene Colan |
| Inks | Gene Colan |
| Reprinted | from Adventures into Terror (Marvel, 1951 series) #14 |
| Script | Chris Claremont |
| Letters | Typeset |
| Genre | science fiction |
| Script | Tony Isabella |
| Pencils | Dave Cockrum |
| Inks | Dave Cockrum |
| Notes | cont'd from CREATURES ON THE LOOSE #21 |
| Genre | Occult |
| Script | Steve Gerber |
| Pencils | Pablo Marcos |
| Inks | Pablo Marcos |
| Genre | Occult |
| Pencils | Bernie Krigstein |
| Inks | Bernie Krigstein |
| Reprinted | from Adventures into Weird Worlds (Marvel, 1952 series) #10 |
| Genre | Occult |
| Script | Chris Claremont |
| Pencils | Don Perlin |
| Inks | Don Perlin |
| Reprinted | In Monsters Unleashed Annual #1 (1975) |