| Issue | #22 |
| Published | December 1979 |
| Cover Price | 1.75 USD |
| Pages | 60 |
| Editing | Will Eisner; Dennis Kitchen; Cat Yronwode |
| Notes | wrap-around cover. Letter and sketch by Terry Austin |
| Genre | adventure; humor |
| Pencils | Will Eisner |
| Inks | Will Eisner |
| Notes | wrap-around cover. Letter and sketch by Terry Austin |
| Reprinted | in Will Eisner Color Treasury (Kitchen Sink Press, Inc., 1981 series) #1 |
| Script | Cat Yronwode |
| Letters | Typeset |
| Notes | indexes Spirit sections 1- 211; 1940-44 |
| Characters | Ebony; Klink |
| Genre | adventure; humor |
| Script | Will Eisner |
| Pencils | Will Eisner |
| Inks | Will Eisner; Jerry Grandenetti |
| Letters | Abe Kanegson |
| Reprinted | from Spirit, The (Register and Tribune Syndicate, 1940 series) #8/31/1947 |
| Characters | Klink; Ward Healy (Intro) |
| Genre | adventure; humor |
| Script | Will Eisner |
| Pencils | Will Eisner |
| Inks | Will Eisner; Jerry Grandenetti |
| Letters | Abe Kanegson |
| Reprinted | from Spirit, The (Register and Tribune Syndicate, 1940 series) #9/7/1947 |
| Characters | Carrion; Silken Floss |
| Genre | adventure; humor |
| Script | Will Eisner |
| Pencils | Will Eisner |
| Inks | Will Eisner; Jerry Grandenetti |
| Letters | Abe Kanegson |
| Reprinted | from Spirit, The (Register and Tribune Syndicate, 1940 series) #9/14/1947 |
| Genre | science fiction |
| Script | Will Eisner |
| Pencils | Will Eisner |
| Inks | Will Eisner |
| Notes | Part 4 |
| Genre | adventure; humor |
| Script | Will Eisner |
| Pencils | John Spranger? |
| Inks | Will Eisner; Jerry Grandenetti |
| Letters | Martin deMuth |
| Notes | remake of #46 |
| Reprinted | from Spirit, The (Register and Tribune Syndicate, 1940 series) #1/5/1947 |
| Script | Dennis Kitchen; Will Eisner |
| Pencils | Dennis Kitchen; Will Eisner |
| Inks | Dennis Kitchen; Will Eisner |
| Notes | Explanation of why the Wally Wood Spirits were run out of order. |
| Genre | science fiction |
| Script | Jules Feiffer |
| Pencils | Wally Wood |
| Inks | Wally Wood |
| Letters | Sam Schwartz |
| Notes | The 2nd Wally Wood Spirit which should have appeared in the previous issue. Pages 4 and 5 transposed accidentally. |
| Reprinted | from Spirit, The (Register and Tribune Syndicate, 1940 series) #8/3/1952 |