| Issue | #22 |
| Published | October 1962 |
| Cover Price | 0.12 USD |
| Pages | 36 |
| Editing | Victor Gorelick |
| Characters | Fly; Fly Girl |
| Genre | superhero |
| Pencils | John Rosenberger |
| Inks | John Rosenberger |
| Characters | Fly; Anti-Fly League [Spider; Metal Monster; Roxr; Lxo III; Dovi; Bra-kr; Karl Rance; Linda]; Cleopatra of the Future |
| Synopsis | Dovi -- the time-travelling villain from the future-- plots to destroy the Fly by using the most beautiful woman from his time to lure the unsuspecting hero into a death trap. |
| Genre | superhero |
| Script | Robert Bernstein |
| Pencils | John Rosenberger |
| Inks | John Rosenberger |
| Characters | Fly; Fly Girl; Turan; Krybrk |
| Synopsis | An alien practical joker wreaks havoc on the earth, including the Fly and Fly Girl. |
| Genre | superhero |
| Script | Robert Bernstein |
| Pencils | John Rosenberger |
| Inks | John Rosenberger |
| Characters | Fly |
| Genre | superhero |
| Letters | typeset |
| Characters | Jaguar |
| Genre | superhero |
| Notes | House ad for the latest issue of Jaguar. |
| Characters | Fly; Fly Girl; Turan |
| Synopsis | A creature from the Fly World travels to earth and saps the powers of the Fly and Fly Girl. |
| Genre | superhero |
| Script | Robert Bernstein |
| Pencils | John Rosenberger |
| Inks | John Rosenberger |