| Issue | #21 |
| Published | March-April 1955 |
| Cover Price | 0.10 USD |
| Pages | 36 |
| Editing | ? |
| Notes | Indicia says "Published bi-monthly". |
| Characters | Lassie |
| Genre | Animal |
| Pencils | ? (painting) |
| Inks | ? (painting) |
| Colors | ? (painting) |
| Notes | Indicia says "Published bi-monthly". |
| Synopsis | Facts about Corn, Chocolate, the Peanut, and the Pineapple |
| Genre | Fact |
| Letters | Typeset |
| Notes | Inside front cover |
| Characters | Lassie; Gerry; Rocky; Timbu; Ralph Jager |
| Synopsis | Lassie and her friends leave Maine on Mr. Carver's power cruiser to go to Florida. With them is Mr. Ralph Jager, a staff illustrator, who does not fancy dogs. |
| Genre | Animal |
| Pencils | Matt Baker |
| Letters | Typeset |
| Notes | Pencils credits for this issue from Overstreet and Jerry Bails. |
| Characters | Lassie; Gerry; Rocky; Timbu; Pablo Mira; Lalo; Tomas |
| Synopsis | Returning to the homestead in the Matto Grosso, Lassie and her friends expect to be met by Lalo, the caretaker, but instead they meet Pablo Mira and two thieftakers who are hunting Lalo for the murder of Mira's partner Tomas. |
| Genre | Animal |
| Pencils | Matt Baker |
| Letters | Typeset |
| Characters | Lassie; Gerry; Rocky; Malo (chief of the Akawos); Kuru (witch doctor) |
| Synopsis | Traveling up the Orinoco in search for the nesting grounds of the scarlet ibis, Lassie, Gerry and Rocky meet the Akawos. |
| Genre | Animal; Jungle |
| Pencils | Matt Baker |
| Letters | Typeset |
| Notes | Story ends on back cover. Inside back cover in black and white. |