| Issue | #3 |
| Published | November 1993 |
| Cover Price | 3.95 |
| Pages | 68 |
| Editing | Danny Fingeroth |
| Characters | Spider-Man; Doctor Octopus |
| Genre | superhero |
| Pencils | Ron Lim |
| Inks | Jim Sanders III |
| Letters | Typeset |
| Characters | FEATURE: Spider-Man; GUESTS: Dilbert Trilby; Torbert Octavius; Mary Octavius; Ben Urich; Mary Alice Anders; Code Blue; VILLAIN: Doctor Octopus |
| Synopsis | Full origin of Dr. Octopus; Doc Ock steals aids infected blood and radioactive isotopes to try and save the life of his first love. |
| Genre | superhero |
| Script | Tom DeFalco |
| Pencils | Ron Lim |
| Inks | Jim Sanders III |
| Colors | John Kalisz |
| Letters | Dave Sharpe |
| Characters | FEATURE: Spider-Man; GUESTS: Corona; Mary Jane Parker; VILLAINS: "The Operator" Flynn; Cedric Forrester; CAMEOS: Hank Pym; Beast |
| Synopsis | Spidey helps Corona break out of her brother's control. |
| Genre | superhero |
| Script | Kurt Busiek |
| Pencils | Aaron Lopresti |
| Inks | Sam DeLaRosa |
| Colors | John Kalisz |
| Letters | John Kalisz |
| Characters | FEATURE: Annex; GUESTS: Dr. Hillman Barto; Code Blue; VILLAINS: Ren-Tech |
| Genre | superhero |
| Script | Jack Harris |
| Pencils | Jesse Orozco |
| Inks | Mark Stegbauer |
| Colors | Renee Witterstaetter |
| Letters | Dave Sharpe |