| Issue | #21 |
| Published | November 1938 |
| Cover Price | 0.10 |
| Pages | 68 |
| Editing | Vincent Sullivan |
| Pencils | Leo O'Mealia |
| Inks | Leo O'Mealia |
| Characters | I: Phillippa Rowen (D), Betty Palmer; V: Big Shot Bettini |
| Genre | detective |
| Script | Gardner Fox |
| Pencils | Fred Guardineer |
| Inks | Fred Guardineer |
| Notes | Speed is shown reading DETECTIVE COMICS! |
| Characters | V: Tom Hayworth, Dr. Avery, Colby (I for all) |
| Genre | detective |
| Script | Will Ely |
| Pencils | Will Ely |
| Inks | Will Ely |
| Characters | V: Smythe (I) |
| Script | Homer Fleming |
| Pencils | Homer Fleming |
| Inks | Homer Fleming |
| Notes | story in black and white |
| Characters | V: Baron Von Mundorf, Lorenzo Rica (I for both) |
| Genre | adventure |
| Script | Jerry Siegel |
| Pencils | Joe Shuster |
| Inks | Joe Shuster |
| Genre | adventure |
| Script | Sax Rohmer |
| Pencils | Leo O'Mealia |
| Inks | Leo O'Mealia |
| Letters | typeset |
| Notes | strip reprints; adapted from THE INSIDIOUS DR. FU MANCHU by Sax Rohmer |
| Script | Gardner Fox (Paul Dean) |
| Letters | typeset |
| Characters | V: Mrs. Warren |
| Genre | detective |
| Script | Gardner Fox? |
| Pencils | Tom Hickey |
| Inks | Tom Hickey |
| Characters | V: Miller and his gang (I for all) |
| Genre | superhero |
| Script | Jim Chambers? |
| Pencils | Jim Chambers |
| Inks | Jim Chambers |
| Characters | V: The Ferrini gang (I) |
| Genre | detective |
| Script | Gardner Fox |
| Characters | V: Seth (I, D); I: Lord Atherton, a girl (D) |
| Genre | detective |
| Script | Jerry Siegel |
| Pencils | Joe Shuster |
| Inks | Joe Shuster |
| Notes | may be out of order in this book |