| Issue | #224 |
| Published | April 1949 |
| Cover Price | 0.10 USD |
| Pages | 36 |
| Editing | ? |
| Notes | Indicia title is "LITTLE IODINE, No. 224." Code number is L.I.O.S. #224-494. Copyright 1949 by King Features Syndicate, Inc. |
| Characters | Little Iodine |
| Genre | children |
| Pencils | Jimmy Hatlo ? |
| Inks | Jimmy Hatlo ? |
| Letters | typeset |
| Notes | Cover says "by Jimmy Hatlo" and may or may not be by him. Cover has "This is a King Feature" bullet. |
| Characters | Little Iodine; Henry Tremblechin; Shalimar |
| Synopsis | Iodine and her friend Shalimar are making money by cleaning people's sofas. |
| Genre | children |
| Script | Jimmy Hatlo ? |
| Pencils | Jimmy Hatlo ? |
| Inks | Jimmy Hatlo ? |
| Notes | Inside front cover; black, red, and white. |
| Characters | Little Iodine; Sharkey; Henry Tremblechin; Mr. Bigdome |
| Synopsis | Iodine finds a stray dog on the street. After cleaning the dog up, her father enters it in a dog show, only to find that the dog belongs to one of Mr. Bigdome's biggest customers. |
| Genre | children |
| Script | Jimmy Hatlo ? |
| Pencils | Jimmy Hatlo ? |
| Inks | Jimmy Hatlo ? |
| Characters | Little Iodine; Henry Tremblechin; Shalimar |
| Synopsis | Iodine and her father go to a masquerade party. Tremblechin dresses as a policeman and Iodine as a burglar. |
| Genre | children |
| Script | Jimmy Hatlo ? |
| Pencils | Jimmy Hatlo ? |
| Inks | Jimmy Hatlo ? |
| Characters | Little Iodine; Henry Tremblechin; Sharkey |
| Synopsis | Iodine's father takes her on a train trip to visit her Aunt Thora. Iodine smuggles Sharkey along in one of her suitcases. |
| Genre | children |
| Script | Jimmy Hatlo ? |
| Pencils | Jimmy Hatlo ? |
| Inks | Jimmy Hatlo ? |
| Characters | Little Iodine; Henry Tremblechin |
| Synopsis | Iodine misbehaves when the family goes to a photographer. |
| Genre | children |
| Script | Jimmy Hatlo ? |
| Pencils | Jimmy Hatlo ? |
| Inks | Jimmy Hatlo ? |
| Notes | Inside back cover; black, red, and white. |
| Characters | Little Iodine; Henry Tremblechin |
| Synopsis | Iodine and her father get business contracts and homework switched. |
| Genre | children |
| Script | Jimmy Hatlo ? |
| Pencils | Jimmy Hatlo ? |
| Inks | Jimmy Hatlo ? |
| Notes | Back cover. |