| Issue | #46 |
| Published | April 1959 |
| Cover Price | 0.25 USD |
| Pages | 52 |
| Editing | Albert B. Feldstein |
| Notes | April Fool cover printed on the BACK cover of magazine. Contents herein is indexed beginning from the front of magazine. |
| Characters | Alfred E. Neuman |
| Genre | humor |
| Pencils | Kelly Freas (painted, signed) |
| Inks | Kelly Freas (painted, signed) |
| Colors | Kelly Freas (painted, signed) |
| Letters | Kelly Freas (painted, signed); typeset |
| Notes | April Fool cover printed on the BACK cover of magazine. Contents herein is indexed beginning from the front of magazine. |
| Synopsis | Parody of ad for RCA Victor color televisions. |
| Genre | satire |
| Script | Al Jaffee |
| Pencils | Kelly Freas (painted, signed) |
| Inks | Kelly Freas (painted, signed) |
| Colors | Kelly Freas (painted, signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. On FRONT cover. |
| Synopsis | Parody of ad for Sanforized Fabric, but trying to convince people NOT to buy the product. |
| Genre | satire |
| Pencils | Kelly Freas (painted) |
| Inks | Kelly Freas (painted) |
| Letters | typeset |
| Notes | Inside front cover. |
| Pencils | various |
| Inks | various |
| Letters | typeset |
| Notes | Art is excerpts from this issue. Instead of usual Alfred E. Neuman quote, masthead quote is from The New Yorker, November 29, 1958. |
| Characters | Alfred E. Neuman |
| Synopsis | House ad for first MAD record album, from RCA Victor. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Letters | typeset |
| Synopsis | House ad for a MAD paperback book. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Letters | typeset |
| Characters | Scribbly Jibbet; Moxie Cowznofsky |
| Synopsis | Letters of comment, mostly about issue #44. |
| Script | Albert B. Feldstein; Irene LaCapria; William Wheaton; Charles Johnson; Dennis Hotaling; Ronald Keeperman; Bob Quick; Roger Goldman; Tom Sabo; Lila Vail; Larry Swanbom; Bob Vogel; Peter Olin; George Willick; Sally Hartley; K. H. Richter; Sheldon Mayer; Ronald Soldberg; Esther O'Mara |
| Pencils | various |
| Inks | various |
| Letters | typeset |
| Notes | Letter from Sheldon Mayer recognizes Scribbly Jibbet. Moxie Cowznofsky is named in letters column of issue #48. |
| Characters | Alfred E. Neuman |
| Synopsis | House ad for pinups suitable for framing. |
| Pencils | Norman Mingo (painted) |
| Inks | Norman Mingo (painted) |
| Letters | typeset |
| Synopsis | House ad for MAD subscriptions. |
| Pencils | George Woodbridge |
| Inks | George Woodbridge |
| Letters | typeset |
| Characters | Gene Rayburn; Steve Allen; Ed Sullivan; Eydie Gorme; Jane Mansfield; Brett Maverick; Henny Youngman; Senior Wences; Mickey Mantle; The Four Aces; Ben Hogan; The Belgian Congo Ballet Company |
| Synopsis | The interesting tv viewing you could have by constantly switching channels between ABC, NBC, and CBS. |
| Genre | humor |
| Script | Gary Belkin |
| Pencils | Mort Drucker (signed) |
| Inks | Mort Drucker (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Synopsis | A man fails to stop a suicide. |
| Genre | humor |
| Script | Don Martin (signed) |
| Pencils | Don Martin (signed) |
| Inks | Don Martin (signed) |
| Letters | typeset |
| Synopsis | Ridiculous extremes to the trend for "real sounds" on stereo records. |
| Genre | satire |
| Script | Tom Koch |
| Pencils | Wally Wood (signed) |
| Inks | Wally Wood (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Synopsis | Injuries caused by modern car features such as automatic windows and tailfins. |
| Genre | humor |
| Script | Al Jaffee |
| Pencils | Bob Clarke (signed) |
| Inks | Bob Clarke (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Characters | Irving Finster; Zelda Zitzlaff |
| Synopsis | Shows how the same photo can be used by many different publications, through cropping. |
| Genre | satire |
| Script | Frank Jacobs |
| Pencils | Joe Orlando |
| Inks | Joe Orlando |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Synopsis | Various things tv western heroes might use as weapons, if the trend away from guns continues. |
| Genre | humor |
| Script | Larry Siegel |
| Pencils | George Woodbridge (signed) |
| Inks | George Woodbridge (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Characters | Miles Davis; Dizzy Gillespie |
| Synopsis | Parodies of ads, using hip language and celebrities. |
| Genre | satire |
| Script | Gary Belkin |
| Pencils | Wally Wood |
| Inks | Wally Wood |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Synopsis | Excerpts from a book written by a dog, on what to look for and how to train a master. |
| Genre | humor |
| Script | Frank Jacobs; Robert Margroff |
| Pencils | George Woodbridge (signed) |
| Inks | George Woodbridge (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Synopsis | Foolish phrases you may need in various foreign countries. |
| Genre | satire |
| Script | Sy Reit |
| Pencils | George Woodbridge |
| Inks | George Woodbridge |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Characters | Frank Lloyd Wrighteous; Mies Van Der Roebuck; Alfred E. Neuman |
| Synopsis | Showing how the beauty of modern architecture is lost when the buildings are jammed in with all the other existing buildings. |
| Genre | satire |
| Script | Al Jaffee |
| Pencils | Bob Clarke (signed) |
| Inks | Bob Clarke (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Synopsis | A man exhibits a disgusting way to choose a book in a bookstore. |
| Genre | humor |
| Script | Don Martin (signed) |
| Pencils | Don Martin (signed) |
| Inks | Don Martin (signed) |
| Letters | typeset |
| Characters | William Shakespeare; Donald Duck; Huey; Dewey; Louie; Pauline Poodle; Dick Tracy; Flattop; Pruneface; Charlie Brown; Lucy Van Pelt; Linus Van Pelt; Schroeder; Snoopy; Pigpen; Hans; Fritz; The Captain; Rex Morgan; Little Orphan Annie; Sandy; Big Daddy Warbucks; Cousin Asp; Dennis The Menace; Nancy; Sluggo; Fritzi Ritz |
| Synopsis | Various comic strips written in the styles of: Paddy Chayefsky; Gilbert & Sullivan; Rudyard Kipling; Walt Whitman; Rogers & Hammerstein; Tennessee Williams; Edgar Allen Poe; Mickey Spillane. |
| Genre | satire |
| Script | Frank Jacobs |
| Pencils | Wally Wood (signed) |
| Inks | Wally Wood (signed) |
| Letters | typeset |
| Synopsis | Fake cheap alternatives to common expensive status symbols. |
| Genre | humor |
| Script | Sy Reit |
| Pencils | Joe Orlando |
| Inks | Joe Orlando |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Synopsis | Showing how theaters can attract more patrons by remodeling to be more like watching tv at home. |
| Genre | humor |
| Script | Dave Berg (signed) |
| Pencils | Dave Berg (signed) |
| Inks | Dave Berg (signed) |
| Letters | typeset |
| Synopsis | Phone ad for Vicejoy Cigarettes. |
| Genre | satire |
| Pencils | Mort Drucker (signed) |
| Inks | Mort Drucker (signed) |
| Letters | typeset |
| Notes | Parody of ad for Viceroy Cigarettes. |
| Characters | Hansel; Gretel; Derrence Clarow; Beauty; Irving Prince [The Beast]; Jack; Sleeping Beauty; Prince Charming; Little Red Riding Hood |
| Synopsis | Thoughts on what happened after the end of several fairy tales. |
| Genre | humor |
| Script | Sy Reit |
| Pencils | Bob Clarke (signed) |
| Inks | Bob Clarke (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Synopsis | A man is surprised at the law enforcement tactics when he violates a "Do Not Pick Flowers" sign. |
| Genre | humor |
| Script | Don Martin (signed) |
| Pencils | Don Martin (signed) |
| Inks | Don Martin (signed) |
| Letters | typeset |
| Characters | Leonard Brenner |
| Synopsis | House ad for fake straight jacket. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Letters | typeset |
| Notes | Leonard is the model with back turned to the reader; named in letters column of MAD #49. Inside back cover. |
| Synopsis | Goofy fake word definitions. |
| Genre | humor |
| Letters | typeset |
| Notes | Appear in the margins of 24 pages of the issue. |