| Issue | #22 |
| Published | 1988 |
| Frequency | annually |
| Cover Price | 1.75 USD; 2.25 CAD; 0.50 GBP |
| Pages | 68 |
| Editing | Jim Salicrup (Editor); Tom DeFalco (Editor-in-Chief) |
| Characters | Spider-Man; Daredevil; Speedball |
| Genre | superhero |
| Pencils | Ron Frenz |
| Inks | Joe Rubinstein |
| Characters | FEATURE: Spider-Man; GUESTS: Daredevil; Speedball (1st); J. Jonah Jameson; Ben Urich; Mary Jane Parker; VILLAINS: Kingpin; Arranger; Purifiers; CAMEO: High Evolutionary |
| Genre | superhero |
| Script | Tom DeFalco (plotter); David Michelinie (scripter) |
| Pencils | Mark Bagley |
| Inks | Mike Esposito |
| Colors | Bob Sharen |
| Letters | Rick Parker |
| Notes | 1st Mark Bagley art on Spider-Man; Speedball created by Steve Ditko and Tom DeFalco; Evolutionary War Crossover; Continued in Fantastic Four Annual #21 |
| Characters | Spider-Man; J. Jonah Jameson; Robbie Robertson |
| Genre | superhero |
| Pencils | Larry Lieber |
| Inks | Frank Giacoia |
| Notes | Ad for Spider-Man newspaper comic strip. |
| Characters | FEATURE: Speedball VILLAIN: Bad Actor |
| Genre | superhero |
| Script | Steve Ditko (plotter); Roger Stern (scripter) |
| Pencils | Steve Ditko |
| Inks | Jackson Guice |
| Colors | Tom Vincent |
| Letters | Rick Parker |
| Genre | superhero |
| Pencils | Janet Jackson |
| Inks | Janet Jackson |
| Notes | Layout of Peter and MJ's Bedford Towers apartment. |
| Characters | FEATURE: The High Evolutionary; GUESTS: Bova; Baron Russoff; Magnus; VILLAINS: Morgan Le Fey; Chthon |
| Genre | superhero |
| Script | Mark Gruenwald |
| Pencils | Ron Lim |
| Inks | Tony DeZuniga |
| Colors | Gregory Wright |
| Letters | Ken Lopez |
| Editing | Ralph Macchio |
| Notes | Evolutionary War Crossover; Continued in Fantastic Four Annual #21 |
| Characters | Spider-Man |
| Genre | superhero |
| Pencils | Larry Lieber |
| Inks | Jack Abel |
| Characters | Spider-Man; Dr. Octopus arms |
| Genre | superhero |
| Pencils | Bob Layton |
| Inks | Bob Layton |