| Issue | #66 |
| Published | October 2000 |
| Frequency | Monthly |
| Cover Price | 3.75 USD; 5.75 CAD |
| Pages | 52 |
| Editing | Axel Alonso |
| Notes | Last issue of the series. |
| Characters | Saint of Killers; Hosts of Heaven |
| Genre | occult |
| Pencils | Glenn Fabry (painted) |
| Inks | Glenn Fabry (painted) |
| Colors | Glenn Fabry (painted) |
| Characters | Jesse Custer; Tulip; God; Cassidy; Saint of Killers |
| Synopsis | Everything gets wrapped up. |
| Genre | occult |
| Script | Garth Ennis |
| Pencils | Steve Dillon |
| Inks | Steve Dillon |
| Colors | Pamela Rambo |
| Letters | Clem Robins |
| Script | Garth Ennis |
| Letters | typeset |
| Notes | Dedication and afterword by Ennis. |
| Characters | Jesse Custer; Cassidy |
| Genre | occult |
| Pencils | Dave Gibbons [as G.] |
| Inks | Dave Gibbons [as G.] |
| Colors | Matt Hollingsworth [as H] |
| Characters | Tulip |
| Genre | occult |
| Pencils | Amanda Conner (signed) |
| Inks | Jimmy Palmiotti (signed) |
| Colors | Matt Hollingsworth (signed) |
| Characters | Herr Starr; the Holy Grail |
| Genre | occult |
| Pencils | Carlos Ezquerra (signed) |
| Inks | Carlos Ezquerra (signed) |
| Characters | Gran'ma Custer; T.C. Custer; Jody Custer |
| Genre | occult |
| Characters | Genesis' Parents |
| Genre | Adventure(Action) |
| Pencils | Dave Johnson (signed) |
| Inks | Dave Johnson (signed) |
| Characters | The Saint of Killers |
| Genre | occult |
| Pencils | J. G. Jones (signed) |
| Inks | J. G. Jones (signed) |
| Colors | Matt Hollingsworth (signed) |
| Characters | Arseface |
| Genre | occult |
| Pencils | Brian Bolland (signed) |
| Inks | Brian Bolland (signed) |
| Colors | Matt Hollingsworth (signed) |
| Characters | Jesse Custer; Tulip; Cassidy; Herr Starr; the Saint of Killers |
| Genre | occult |
| Pencils | Bruce Timm [as B.T.] |
| Inks | Bruce Timm [as B.T.] |