| Issue | #21 |
| Published | March 1955 |
| Cover Price | 0.10 USD |
| Pages | 36 |
| Editing | Harvey Kurtzman |
| Notes | Cover is a satire of Johnson Smith & Co. novelty catalog ads. Includes first image of "Alfred" on a MAD cover. |
| Characters | Alfred [Alfred E. Neuman] |
| Genre | satire |
| Letters | typeset |
| Notes | Cover is a satire of Johnson Smith & Co. novelty catalog ads. Includes first image of "Alfred" on a MAD cover. |
| Letters | typeset |
| Notes | Includes announcement for the first pocket book MAD collection from Ballantine Books (no title given). |
| Characters | Poopeye; Mazola Oil; Swee'back [Mad-Man]; Mammy Jokeum; Mammy's son; Melvin of the Apes; Superduperman [Clark Bent]; Windy |
| Synopsis | Poopeye beats up other comic strongmen hired by the broccoli king to get rid of Poopeye. |
| Genre | satire |
| Script | Harvey Kurtzman ? |
| Pencils | Bill Elder [as B. Elder] |
| Inks | Bill Elder [as B. Elder] |
| Colors | Marie Severin |
| Notes | Parody of Popeye comic strip. |
| Reprinted | in Mad Strikes Back (Ballantine Books, 1955 series) #106 |
| Synopsis | A look at what might be happening in various sports if they were recorded by a slow motion camera. |
| Genre | humor |
| Script | Harvey Kurtzman ? |
| Pencils | Jack Davis (signed) |
| Inks | Jack Davis (signed) |
| Colors | Marie Severin |
| Reprinted | in Bedside Mad, The (Signet Books, 1959 series) #P3520; Bedside Mad, The (Signet Books, 1959 series) #D2316; Bedside Mad, The (Signet Books, 1959 series) #S1647; Inside Mad (Ballantine Books, 1955 series) #124 |
| Synopsis | Parody ads for "How To Hypnotize", "Get Prizes...Make Money", "Rubber Bubble Gum", "Tromp Stamps Co.", "Ded Ryder Cowboy Carbine", and "Alwett Physical Training Course." |
| Genre | satire |
| Script | Harvey Kurtzman ? |
| Pencils | Bill Elder (signed) |
| Inks | Bill Elder (signed) |
| Colors | Marie Severin |
| Reprinted | in Inside Mad (Ballantine Books, 1955 series) #124 [Rubber Bubble Gum only] |
| Colors | Marie Severin |
| Notes | House ads for 5 new E. C. comics, ½ page each plus subscription form. |
| Characters | Terry; Joey; John Friendly; Charlie; Edie |
| Synopsis | Everyone Terry knows is killed by John Friendly's thugs. |
| Genre | satire |
| Script | Harvey Kurtzman ? |
| Pencils | Wallace Wood (signed) |
| Inks | Wallace Wood (signed) |
| Colors | Marie Severin |
| Notes | Parody of the movie "On The Waterfront." |
| Letters | typeset |
| Notes | A Christmas and New Year message from the editors and staff. |
| Letters | typeset |
| Notes | Ad for B-J Co's ju-jitsu training. |
| Letters | typeset |
| Notes | Ad for electronics training from National Schools. |
| Letters | typeset |
| Notes | Ad for novelty catalog. |
| Pencils | ?; ? (photo) |
| Inks | ?; ? (photo) |
| Letters | typeset |
| Notes | Ad for Powerhouse binoculars from Thoresen's. Inside back cover. |
| Letters | typeset |
| Notes | Ad for FUNman religious wall motto sales. |