| Issue | #591 |
| Published | June 2001 |
| Cover Price | $2.25/$3.75 CAD |
| Pages | 36 |
| Editing | Eddie Berganza; Tom Palmer, Jr. (assistant) |
| Notes | 2001 Diamond #23 |
| Characters | Superman |
| Genre | Superhero |
| Pencils | Dale Keown |
| Inks | Dale Keown |
| Colors | Tanya Horie; Richard Horie |
| Notes | 2001 Diamond #23 |
| Characters | Superman [Clark Kent; Kal-El]; Lois Lane; Korsa; Kayl; Taya (dies); Loodo |
| Synopsis | Superman returns home after he apparently destroys Viroxx, but the virus strikes back at the thing he holds closest to his heart: Lois. Superman watches in horror as his wife is transformed into a mindless anti-body and is sent to claim more worlds for Viroxx. [per solicitation] |
| Genre | Superhero |
| Script | Marv Wolfman |
| Pencils | Paco Medina |
| Inks | Walden Wong |
| Colors | Studio F |
| Letters | Chris Eliopolous |
| Notes | Story continued from Superman (1987) #169 and continues in Superman: The Man of Steel #113. |
| Letters | Typeset |
| Notes | Mike McAvennie answers letters from readers. |