| Issue | #1 |
| Published | May 2000 |
| Frequency | monthly |
| Cover Price | 1.99 USD |
| Pages | 36 |
| Editing | Heidi MacDonald; Harvey Richards (assistant editor) |
| Characters | Blossom; Buttercup; Bubbles; Twitchy |
| Genre | superhero; children |
| Pencils | Phil Moy (signed) |
| Inks | Phil Moy (signed) |
| Characters | Blossom; Buttercup; Bubbles; Twitchy; Mojo Jojo; The Mayor; Professor Utonium; Sara Bellum (cameo) |
| Synopsis | When a bystanding squirrel is injured during a battle with Mojo Jojo, the Powerpuff Girls bring it home and name it Twitchy. Bubbles also feeds the squirrel some Chemical X, which gives it super-powers and causes lots of trouble. |
| Genre | superhero; children |
| Script | Jennifer Moore; Sean Carolan |
| Pencils | Phil Moy |
| Inks | Phil Moy |
| Colors | Dave Tanguay |
| Letters | Janice Chiang |